Abstract
5-Aryl-1,3-dioxolan-4-one heterocycles derived from mandelic acid derivatives and hexafluoroacetone have been identified as new and effective pro-nucleophiles in highly diastereo- and enantioselective Michael addition reactions to nitro olefins catalyzed by bifunctional epi-9-amino9-deoxy cinchona alkaloid derivatives. Diastereoselectivities up to 98% and enantioselectivities up to 89% for a range of nitro olefins and 5-aryl-1,3-dioxolan-4-ones under mild reaction conditions are reported.
Original language | English |
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Pages (from-to) | 2107-2110 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 9 |
Issue number | 11 |
DOIs | |
Publication status | Published - 24 May 2007 |
Externally published | Yes |