Projects per year
Abstract
A synthetic method to prepare 1-alkyl-substituted-pyrazolidin-3-ones efficiently that relies on the 4CzPN-mediated alkylation of azomethine imines by 4-alkyl-substituted-1,4-dihydropyridines (DHPs) under blue light emitting diode (LED) light (λmax = 456 nm) is reported. An approach that exploits the ability of blue LED light to initiate the acylation of the imine substrate by 4-acyl-substituted-DHPs to give 1-acyl-substituted-pyrazolidin-3-ones is also presented. Achieved under mild reaction conditions at room temperature, the synthetic protocol was shown to tolerate a broad range of functional groups to afford the corresponding 1-substituted-pyrazolidin-3-ones in yields up to 99%.
Original language | English |
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Pages (from-to) | 19421-19427 |
Number of pages | 7 |
Journal | New Journal of Chemistry |
Volume | 47 |
Issue number | 42 |
DOIs | |
Publication status | Published - 14 Nov 2023 |
Projects
- 1 Finished
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New catalytic alkyne cyclisation strategies for complex molecule synthesis
18/01/21 → 17/01/25
Project: Research