Organization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish

Arianna Servili, Yann Le Page, Jerome Leprince, Alain Caraty, Sebastian Escobar, Ishwar Parhar, J Y Seong, Hubert Vaudry, Oliver Kah

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    Abstract

    The aim of this work was then to obtain detailed information regarding the organization of the Kiss1 and Kiss2 systems in zebrafish brain. To this end we produced specific antibodies that are able to unambiguously distinguish zebrafish preproKiss1 from preproKiss2. Another aim was to map the kiss1r and kiss2r in relation to Kiss1 and Kiss2 neuronal projections and to document potential interactions between Kiss and GnRH systems. Finally, we aimed at looking at the effects of estradiol on kiss1 and kiss2 gene expression.
    Original languageEnglish
    Pages (from-to)1527 - 1540
    Number of pages14
    JournalEndocrinology
    Volume152
    Issue number4
    DOIs
    Publication statusPublished - 2011

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