Organization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish

Arianna Servili; Yann Le Page; Jerome Leprince; Alain Caraty; Sebastian Escobar; Ishwar Parhar; J Y Seong; Hubert Vaudry; Oliver Kah

doi:10.1210/en.2010-0948

Organization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish

Arianna Servili, Yann Le Page, Jerome Leprince, Alain Caraty, Sebastian Escobar, Ishwar Parhar, J Y Seong, Hubert Vaudry, Oliver Kah

Malaysia Jeffrey Cheah Sch of Med & HS

Research output: Contribution to journal › Article › Research › peer-review

190 Citations (Scopus)

Abstract

The aim of this work was then to obtain detailed information regarding the organization of the Kiss1 and Kiss2 systems in zebrafish brain. To this end we produced specific antibodies that are able to unambiguously distinguish zebrafish preproKiss1 from preproKiss2. Another aim was to map the kiss1r and kiss2r in relation to Kiss1 and Kiss2 neuronal projections and to document potential interactions between Kiss and GnRH systems. Finally, we aimed at looking at the effects of estradiol on kiss1 and kiss2 gene expression.

Original language	English
Pages (from-to)	1527 - 1540
Number of pages	14
Journal	Endocrinology
Volume	152
Issue number	4
DOIs	https://doi.org/10.1210/en.2010-0948
Publication status	Published - 2011

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10.1210/en.2010-0948

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abstract = "The aim of this work was then to obtain detailed information regarding the organization of the Kiss1 and Kiss2 systems in zebrafish brain. To this end we produced specific antibodies that are able to unambiguously distinguish zebrafish preproKiss1 from preproKiss2. Another aim was to map the kiss1r and kiss2r in relation to Kiss1 and Kiss2 neuronal projections and to document potential interactions between Kiss and GnRH systems. Finally, we aimed at looking at the effects of estradiol on kiss1 and kiss2 gene expression.",

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AU - Le Page, Yann

AU - Leprince, Jerome

AU - Caraty, Alain

AU - Escobar, Sebastian

AU - Parhar, Ishwar

AU - Seong, J Y

AU - Vaudry, Hubert

AU - Kah, Oliver

PY - 2011

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AB - The aim of this work was then to obtain detailed information regarding the organization of the Kiss1 and Kiss2 systems in zebrafish brain. To this end we produced specific antibodies that are able to unambiguously distinguish zebrafish preproKiss1 from preproKiss2. Another aim was to map the kiss1r and kiss2r in relation to Kiss1 and Kiss2 neuronal projections and to document potential interactions between Kiss and GnRH systems. Finally, we aimed at looking at the effects of estradiol on kiss1 and kiss2 gene expression.

UR - http://endo.endojournals.org/content/152/4/1527.full.pdf+html

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Organization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish

Abstract

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