Organic nitrate functional nanoparticles for the glutathione-triggered slow-release of nitric oxide

Hien Thi Thu Duong, Amy Ho, Thomas Paul Davis, Cyrille Boyer

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12 Citations (Scopus)


Nitrate-containing amphiphilic block copolymer chains were self-assembled into micellar nanostructures as a reservoir for the slow-release delivery of nitric oxide (NO). Poly(oligo(ethylene glycol) methyl ether methacrylate)-block- poly(vinyl benzyl chloride-co-styrene) was prepared by reversible addition fragmentation chain transfer (RAFT) polymerization. Pendant chloro- groups in the polymer backbone were reacted with silver nitrate (AgNO3) to introduce nitrate functionality. The nitrate-containing micelles proved to be stable in water, with no detectableNOrelease. The release ofNOwas then triggered by exposure to glutathione, and it was found that 36 and 99 of NO was released at 37 and 60? C, respectively, after 21 h.
Original languageEnglish
Pages (from-to)2099 - 2103
Number of pages5
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Issue number15
Publication statusPublished - 2014

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