Organic nitrate functional nanoparticles for the glutathione-triggered slow-release of nitric oxide

Hien Thi Thu Duong; Amy Ho; Thomas Paul Davis; Cyrille Boyer

doi:10.1002/pola.27221

Organic nitrate functional nanoparticles for the glutathione-triggered slow-release of nitric oxide

Hien Thi Thu Duong, Amy Ho, Thomas Paul Davis, Cyrille Boyer

Drug Delivery Disposition & Dynamics

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Abstract

Nitrate-containing amphiphilic block copolymer chains were self-assembled into micellar nanostructures as a reservoir for the slow-release delivery of nitric oxide (NO). Poly(oligo(ethylene glycol) methyl ether methacrylate)-block- poly(vinyl benzyl chloride-co-styrene) was prepared by reversible addition fragmentation chain transfer (RAFT) polymerization. Pendant chloro- groups in the polymer backbone were reacted with silver nitrate (AgNO3) to introduce nitrate functionality. The nitrate-containing micelles proved to be stable in water, with no detectableNOrelease. The release ofNOwas then triggered by exposure to glutathione, and it was found that 36 and 99 of NO was released at 37 and 60? C, respectively, after 21 h.

Original language	English
Pages (from-to)	2099 - 2103
Number of pages	5
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	52
Issue number	15
DOIs	https://doi.org/10.1002/pola.27221
Publication status	Published - 2014

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title = "Organic nitrate functional nanoparticles for the glutathione-triggered slow-release of nitric oxide",

abstract = "Nitrate-containing amphiphilic block copolymer chains were self-assembled into micellar nanostructures as a reservoir for the slow-release delivery of nitric oxide (NO). Poly(oligo(ethylene glycol) methyl ether methacrylate)-block- poly(vinyl benzyl chloride-co-styrene) was prepared by reversible addition fragmentation chain transfer (RAFT) polymerization. Pendant chloro- groups in the polymer backbone were reacted with silver nitrate (AgNO3) to introduce nitrate functionality. The nitrate-containing micelles proved to be stable in water, with no detectableNOrelease. The release ofNOwas then triggered by exposure to glutathione, and it was found that 36 and 99 of NO was released at 37 and 60? C, respectively, after 21 h.",

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AU - Ho, Amy

AU - Davis, Thomas Paul

AU - Boyer, Cyrille

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Y1 - 2014

N2 - Nitrate-containing amphiphilic block copolymer chains were self-assembled into micellar nanostructures as a reservoir for the slow-release delivery of nitric oxide (NO). Poly(oligo(ethylene glycol) methyl ether methacrylate)-block- poly(vinyl benzyl chloride-co-styrene) was prepared by reversible addition fragmentation chain transfer (RAFT) polymerization. Pendant chloro- groups in the polymer backbone were reacted with silver nitrate (AgNO3) to introduce nitrate functionality. The nitrate-containing micelles proved to be stable in water, with no detectableNOrelease. The release ofNOwas then triggered by exposure to glutathione, and it was found that 36 and 99 of NO was released at 37 and 60? C, respectively, after 21 h.

AB - Nitrate-containing amphiphilic block copolymer chains were self-assembled into micellar nanostructures as a reservoir for the slow-release delivery of nitric oxide (NO). Poly(oligo(ethylene glycol) methyl ether methacrylate)-block- poly(vinyl benzyl chloride-co-styrene) was prepared by reversible addition fragmentation chain transfer (RAFT) polymerization. Pendant chloro- groups in the polymer backbone were reacted with silver nitrate (AgNO3) to introduce nitrate functionality. The nitrate-containing micelles proved to be stable in water, with no detectableNOrelease. The release ofNOwas then triggered by exposure to glutathione, and it was found that 36 and 99 of NO was released at 37 and 60? C, respectively, after 21 h.

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JO - Journal of Polymer Science, Part A: Polymer Chemistry

JF - Journal of Polymer Science, Part A: Polymer Chemistry

SN - 0887-624X

IS - 15

ER -

Organic nitrate functional nanoparticles for the glutathione-triggered slow-release of nitric oxide

Abstract

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