TY - JOUR
T1 - Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging
AU - Li, Benhao
AU - Zhao, Mengyao
AU - Feng, Lishuai
AU - Dou, Chaoran
AU - Ding, Suwan
AU - Zhou, Gang
AU - Lu, Lingfei
AU - Zhang, Hongxin
AU - Chen, Feiya
AU - Li, Xiaomin
AU - Li, Guangfeng
AU - Zhao, Shichang
AU - Jiang, Chunyu
AU - Wang, Yan
AU - Zhao, Dongyuan
AU - Cheng, Yingsheng
AU - Zhang, Fan
N1 - Funding Information:
This work was supported by the National Key R&D Program of China (2017YFA0207303), National Natural Science Foundation of China (21725502 and 51961145403), and Key Basic Research Program of Science and Technology Commission of Shanghai Municipality (17JC1400100 and 19490713100).
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/6/18
Y1 - 2020/6/18
N2 - Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (~ 5–60 min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000 nm. Thanks to the long blood circulation time (half-life of 3.2 h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties.
AB - Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (~ 5–60 min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000 nm. Thanks to the long blood circulation time (half-life of 3.2 h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties.
UR - https://www.scopus.com/pages/publications/85086693923
U2 - 10.1038/s41467-020-16924-z
DO - 10.1038/s41467-020-16924-z
M3 - Article
C2 - 32555157
AN - SCOPUS:85086693923
SN - 2041-1723
VL - 11
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 3102
ER -