Orf virus immuno-modulation and the host immune response

David M. Haig; Jackie Thomson; Colin McInnes; Catherine McCaughan; Wendy Imlach; Andrew Mercer; Stephen Fleming

doi:10.1016/S0165-2427(02)00087-9

Orf virus immuno-modulation and the host immune response

David M. Haig, Jackie Thomson, Colin McInnes, Catherine McCaughan, Wendy Imlach, Andrew Mercer, Stephen Fleming

Research output: Contribution to journal › Article › Research › peer-review

37 Citations (Scopus)

Abstract

Orf virus encodes a range of immuno-modulatory genes that interfere with host anti-virus immune and inflammatory effector mechanisms. The function of these reflects the pathogenesis of orf. The orf virus interferon resistance protein (OVIFNR) and virus IL-10 (vIL-10) inhibit interferon production and activity. In addition the vIL-10 suppresses inflammatory cytokine production by activated macrophages and keratinocytes. The virus GM-CSF inhibitory factor (GIF) is a novel virus protein that binds to and inhibits the biological activity of GM-CSF and IL-2. Together, these immuno-modulators target key effector mechanisms of host anti-virus immunity to allow time for virus replication in epidermal cells.

Original language	English
Pages (from-to)	395-399
Number of pages	5
Journal	Veterinary Immunology and Immunopathology
Volume	87
Issue number	3-4
DOIs	https://doi.org/10.1016/S0165-2427(02)00087-9
Publication status	Published - 2002
Externally published	Yes

Keywords

Interleukin-10
Poxvirus
Sheep

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AU - Haig, David M.

AU - Thomson, Jackie

AU - McInnes, Colin

AU - McCaughan, Catherine

AU - Imlach, Wendy

AU - Mercer, Andrew

AU - Fleming, Stephen

PY - 2002

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AB - Orf virus encodes a range of immuno-modulatory genes that interfere with host anti-virus immune and inflammatory effector mechanisms. The function of these reflects the pathogenesis of orf. The orf virus interferon resistance protein (OVIFNR) and virus IL-10 (vIL-10) inhibit interferon production and activity. In addition the vIL-10 suppresses inflammatory cytokine production by activated macrophages and keratinocytes. The virus GM-CSF inhibitory factor (GIF) is a novel virus protein that binds to and inhibits the biological activity of GM-CSF and IL-2. Together, these immuno-modulators target key effector mechanisms of host anti-virus immunity to allow time for virus replication in epidermal cells.

KW - Interleukin-10

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Orf virus immuno-modulation and the host immune response

Abstract

Keywords

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