Abstract
Orf virus encodes a range of immuno-modulatory genes that interfere with host anti-virus immune and inflammatory effector mechanisms. The function of these reflects the pathogenesis of orf. The orf virus interferon resistance protein (OVIFNR) and virus IL-10 (vIL-10) inhibit interferon production and activity. In addition the vIL-10 suppresses inflammatory cytokine production by activated macrophages and keratinocytes. The virus GM-CSF inhibitory factor (GIF) is a novel virus protein that binds to and inhibits the biological activity of GM-CSF and IL-2. Together, these immuno-modulators target key effector mechanisms of host anti-virus immunity to allow time for virus replication in epidermal cells.
Original language | English |
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Pages (from-to) | 395-399 |
Number of pages | 5 |
Journal | Veterinary Immunology and Immunopathology |
Volume | 87 |
Issue number | 3-4 |
DOIs | |
Publication status | Published - 2002 |
Externally published | Yes |
Keywords
- Interleukin-10
- Poxvirus
- Sheep