Orbitofrontal volumes in early adolescence predict initiation of cannabis use: a 4-year longitudinal and prospective study

Ali Cheetham, Nicholas B Allen, Sarah Whittle, Julian G Simmons, Murat Yucel, Dan Lubman

Research output: Contribution to journalArticleResearchpeer-review

116 Citations (Scopus)

Abstract

There is growing evidence that long-term, heavy cannabis use is associated with alterations in regional brain volumes. Although these changes are frequently attributed to the neurotoxic effects of cannabis, it is possible that some abnormalities might predate use and represent markers of vulnerability. To date, no studies have examined whether structural brain abnormalities are present before the onset of cannabis use. This study aims to determine whether adolescents who have initiated cannabis use early (i.e., before age 17 years) show premorbid structural abnormalities in the amygdala, hippocampus, orbitofrontal cortex, and anterior cingulate cortex.
Original languageEnglish
Pages (from-to)684 - 692
Number of pages9
JournalBiological Psychiatry
Volume71
Issue number8
DOIs
Publication statusPublished - 2012

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