Orbitofrontal sulcogyral patterns are related to temperamental risk for psychopathology

Sarah Whittle, Cali Bartholomeusz, Murat Yucel, Meg Dennison, Nandita Vijayakumar, Nicholas Brian Allen

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)


There are marked individual differences in the pattern of cortical (sulcogyral) folding in the orbitofrontal cortex (OFC), and there is a growing literature suggesting that these individual differences are associated with risk for psychotic disorders. To date, however, no study has investigated whether OFC folding patterns are associated with broader risk factors relevant to a range of psychopathology. This study helps address this knowledge gap by examining whether OFC sulcogyral folding patterns are associated with putative risk factors, specifically affective temperament and psychiatric symptoms, in a large community sample (N = 152) of adolescents. Results showed that the most common pattern of folding ( Type I , marked by discontinuity of the medial orbital sulcus and continuity of the lateral orbital sulcus) was associated with low levels of Surgency, high levels of Negative Affectivity (in girls) and higher depressive symptoms. This pattern was also associated with reduced thickness of OFC gray matter. Overall, the findings, combined with previous work, suggest some specificity of neurodevelopmental risk for different types of psychopathology. Thus, these results have the potential to inform the early identification of at-risk individuals
Original languageEnglish
Pages (from-to)232-239
Number of pages8
JournalSocial Cognitive and Affective Neuroscience
Issue number2
Publication statusPublished - Feb 2014
Externally publishedYes


  • gyrification
  • temperament
  • orbitofrontal cortex
  • risk
  • adolescence

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