Oral Paracetamol for Patent Ductus Arteriosus Rescue Closure

Pramod Pharande, Hadley Watson, Kenneth Tan, Arvind Sehgal

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The objective of this study was to ascertain the efficacy of oral paracetamol in closing a symptomatic patent ductus arteriosus (PDA) when used as ‘rescue’ option. After obtaining ethics approval, a retrospective appraisal of the data from April 2014 to July 2015 was performed. Infants who were administered oral paracetamol either after unsuccessful therapy with ibuprofen or where it was considered contraindicated were included. A previously published echocardiographic scoring schema to stratify for ductal disease severity was used. Using univariate analysis, characteristics of infants with successful closure were compared with partial (a priori reduction in composite score by ≥ 50% of pretreatment) or no closure. Twenty infants with gestation age and birthweight of 25.7 ± 1.5 weeks and 724.1 ± 143 g, respectively, were studied. Complete closure was noted in 10 (50%) infants with additional four infants showing a significant reduction in haemodynamic shunting. Gestational age at birth and at therapy, chronological age at therapy, birthweight and total fluid intake were comparable between the two groups. The pre-therapy composite score had a significant association with successful closure (the higher the echocardiographic score, the lesser the closure). Concomitant furosemide therapy and late-onset sepsis had a high likelihood ratio of unsuccessful closure (11.01 [2-tailed, p = 0.005] and 5.3 [2-tailed, p = 0.07]), respectively. Oral paracetamol may be a possible therapeutic option in premature infants where therapy with first-line agents is unsuccessful or contraindicated. Concomitant sepsis and furosemide administration may affect successful therapy.

Original languageEnglish
Pages (from-to)183-90
Number of pages8
JournalPediatric Cardiology
Volume39
Issue number1
DOIs
Publication statusPublished - Jan 2018

Keywords

  • Paracetamol
  • Patent ductus arteriosus
  • Rescue

Cite this

Pharande, Pramod ; Watson, Hadley ; Tan, Kenneth ; Sehgal, Arvind. / Oral Paracetamol for Patent Ductus Arteriosus Rescue Closure. In: Pediatric Cardiology. 2018 ; Vol. 39, No. 1. pp. 183-90.
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Oral Paracetamol for Patent Ductus Arteriosus Rescue Closure. / Pharande, Pramod; Watson, Hadley; Tan, Kenneth; Sehgal, Arvind.

In: Pediatric Cardiology, Vol. 39, No. 1, 01.2018, p. 183-90.

Research output: Contribution to journalArticleResearchpeer-review

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