Abstract
Lipid-based formulations have been successfully and commercially applied to the formulation of cyclosporine, saquinavir, ritonavir, dutasteride, and amprenavir. The more widespread application of lipid-based formulations has, however, been hampered by the incorrect perception that these types of products are difficult and time-consuming to develop. This chapter briefly outlines some of the issues involved with in vitro assessment of lipid-based formulayions, but will concentrate primarily on those issues pertaining to the use of in vivo preclinical data to identify the potential utility of lipid-based formulations; assess the relative importance of lymphatic transport in drug absoprtion, and screen for and develop effective lipid-based formulation strategies.
| Original language | English |
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| Title of host publication | Oral lipid based formulations: Enhancing the bioavailability of poorly water-soluble drugs |
| Editors | David J Hauss |
| Place of Publication | New York USA |
| Publisher | Informa Healthcare USA |
| Pages | 185 - 205 |
| Number of pages | 21 |
| ISBN (Print) | 978-0-8247-2945-5 |
| Publication status | Published - 2007 |