Oral lipid-based formulations: using preclinical data to dictate formulation strategies for poorly water-soluble drugs

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Lipid-based formulations have been successfully and commercially applied to the formulation of cyclosporine, saquinavir, ritonavir, dutasteride, and amprenavir. The more widespread application of lipid-based formulations has, however, been hampered by the incorrect perception that these types of products are difficult and time-consuming to develop. This chapter briefly outlines some of the issues involved with in vitro assessment of lipid-based formulayions, but will concentrate primarily on those issues pertaining to the use of in vivo preclinical data to identify the potential utility of lipid-based formulations; assess the relative importance of lymphatic transport in drug absoprtion, and screen for and develop effective lipid-based formulation strategies.
Original languageEnglish
Title of host publicationOral lipid based formulations: Enhancing the bioavailability of poorly water-soluble drugs
EditorsDavid J Hauss
Place of PublicationNew York USA
PublisherInforma Healthcare USA
Pages185 - 205
Number of pages21
ISBN (Print)978-0-8247-2945-5
Publication statusPublished - 2007

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