Oral lipid-based formulations: using preclinical data to dictate formulation strategies for poorly water-soluble drugs

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Lipid-based formulations have been successfully and commercially applied to the formulation of cyclosporine, saquinavir, ritonavir, dutasteride, and amprenavir. The more widespread application of lipid-based formulations has, however, been hampered by the incorrect perception that these types of products are difficult and time-consuming to develop. This chapter briefly outlines some of the issues involved with in vitro assessment of lipid-based formulayions, but will concentrate primarily on those issues pertaining to the use of in vivo preclinical data to identify the potential utility of lipid-based formulations; assess the relative importance of lymphatic transport in drug absoprtion, and screen for and develop effective lipid-based formulation strategies.
Original languageEnglish
Title of host publicationOral lipid based formulations: Enhancing the bioavailability of poorly water-soluble drugs
EditorsDavid J Hauss
Place of PublicationNew York USA
PublisherInforma Healthcare
Pages185 - 205
Number of pages21
ISBN (Print)978-0-8247-2945-5
Publication statusPublished - 2007

Cite this

Porter, C. J., & Charman, W. N. (2007). Oral lipid-based formulations: using preclinical data to dictate formulation strategies for poorly water-soluble drugs. In D. J. Hauss (Ed.), Oral lipid based formulations: Enhancing the bioavailability of poorly water-soluble drugs (pp. 185 - 205). New York USA: Informa Healthcare.
Porter, Christopher John ; Charman, William Neil. / Oral lipid-based formulations: using preclinical data to dictate formulation strategies for poorly water-soluble drugs. Oral lipid based formulations: Enhancing the bioavailability of poorly water-soluble drugs. editor / David J Hauss. New York USA : Informa Healthcare, 2007. pp. 185 - 205
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Porter, CJ & Charman, WN 2007, Oral lipid-based formulations: using preclinical data to dictate formulation strategies for poorly water-soluble drugs. in DJ Hauss (ed.), Oral lipid based formulations: Enhancing the bioavailability of poorly water-soluble drugs. Informa Healthcare, New York USA, pp. 185 - 205.

Oral lipid-based formulations: using preclinical data to dictate formulation strategies for poorly water-soluble drugs. / Porter, Christopher John; Charman, William Neil.

Oral lipid based formulations: Enhancing the bioavailability of poorly water-soluble drugs. ed. / David J Hauss. New York USA : Informa Healthcare, 2007. p. 185 - 205.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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Porter CJ, Charman WN. Oral lipid-based formulations: using preclinical data to dictate formulation strategies for poorly water-soluble drugs. In Hauss DJ, editor, Oral lipid based formulations: Enhancing the bioavailability of poorly water-soluble drugs. New York USA: Informa Healthcare. 2007. p. 185 - 205