Lipid-based formulations have been successfully and commercially applied to the formulation of cyclosporine, saquinavir, ritonavir, dutasteride, and amprenavir. The more widespread application of lipid-based formulations has, however, been hampered by the incorrect perception that these types of products are difficult and time-consuming to develop. This chapter briefly outlines some of the issues involved with in vitro assessment of lipid-based formulayions, but will concentrate primarily on those issues pertaining to the use of in vivo preclinical data to identify the potential utility of lipid-based formulations; assess the relative importance of lymphatic transport in drug absoprtion, and screen for and develop effective lipid-based formulation strategies.
|Title of host publication||Oral lipid based formulations: Enhancing the bioavailability of poorly water-soluble drugs|
|Editors||David J Hauss|
|Place of Publication||New York USA|
|Publisher||Informa Healthcare USA|
|Pages||185 - 205|
|Number of pages||21|
|Publication status||Published - 2007|