Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

George David Batty; Qing Li; Rachel Huxley; Sophia Zoungas; Barbara Taylor; Bruce Neal; Bastiaan E de Galan; M Woodward; Stephen B Harrap; Stephen Colagiuri; Anushka Patel; John P Chalmers

doi:10.1016/j.eurpsy.2011.07.005

Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

George David Batty, Qing Li, Rachel Huxley, Sophia Zoungas, Barbara Taylor, Bruce Neal, Bastiaan E de Galan, M Woodward, Stephen B Harrap, Stephen Colagiuri, Anushka Patel, John P Chalmers

Health Systems Services & Policy

Research output: Contribution to journal › Article › Research › peer-review

106 Citations (Scopus)

Abstract

Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55?88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95 confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.

Original language	English
Pages (from-to)	49 - 52
Number of pages	4
Journal	European Psychiatry
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.eurpsy.2011.07.005
Publication status	Published - 2013

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10.1016/j.eurpsy.2011.07.005

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Batty, G. D., Li, Q., Huxley, R., Zoungas, S., Taylor, B., Neal, B., de Galan, B. E., Woodward, M., Harrap, S. B., Colagiuri, S., Patel, A., & Chalmers, J. P. (2013). Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial. European Psychiatry, 28(1), 49 - 52. https://doi.org/10.1016/j.eurpsy.2011.07.005

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title = "Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial",

abstract = "Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55?88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95 confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.",

author = "Batty, {George David} and Qing Li and Rachel Huxley and Sophia Zoungas and Barbara Taylor and Bruce Neal and {de Galan}, {Bastiaan E} and M Woodward and Harrap, {Stephen B} and Stephen Colagiuri and Anushka Patel and Chalmers, {John P}",

year = "2013",

doi = "10.1016/j.eurpsy.2011.07.005",

language = "English",

volume = "28",

pages = "49 -- 52",

journal = "European Psychiatry",

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publisher = "Cambridge University Press",

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Batty, GD, Li, Q, Huxley, R, Zoungas, S, Taylor, B, Neal, B, de Galan, BE, Woodward, M, Harrap, SB, Colagiuri, S, Patel, A & Chalmers, JP 2013, 'Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial', European Psychiatry, vol. 28, no. 1, pp. 49 - 52. https://doi.org/10.1016/j.eurpsy.2011.07.005

Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial. / Batty, George David; Li, Qing; Huxley, Rachel et al.
In: European Psychiatry, Vol. 28, No. 1, 2013, p. 49 - 52.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

AU - Batty, George David

AU - Li, Qing

AU - Huxley, Rachel

AU - Zoungas, Sophia

AU - Taylor, Barbara

AU - Neal, Bruce

AU - de Galan, Bastiaan E

AU - Woodward, M

AU - Harrap, Stephen B

AU - Colagiuri, Stephen

AU - Patel, Anushka

AU - Chalmers, John P

PY - 2013

Y1 - 2013

N2 - Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55?88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95 confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.

AB - Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55?88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95 confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.

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DO - 10.1016/j.eurpsy.2011.07.005

M3 - Article

SN - 0924-9338

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SP - 49

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JO - European Psychiatry

JF - European Psychiatry

IS - 1

ER -

Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

Abstract

UN SDGs

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Preventing weight gain in young to mid-aged women living in rural communities;a cluster randomised controlled trial

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Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

Abstract

UN SDGs

Access to Document

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Preventing weight gain in young to mid-aged women living in rural communities;a cluster randomised controlled trial

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