Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

George David Batty, Qing Li, Rachel Huxley, Sophia Zoungas, Barbara Taylor, Bruce Neal, Bastiaan E de Galan, M Woodward, Stephen B Harrap, Stephen Colagiuri, Anushka Patel, John P Chalmers

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Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55?88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95 confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.
Original languageEnglish
Pages (from-to)49 - 52
Number of pages4
JournalEuropean Psychiatry
Issue number1
Publication statusPublished - 2013

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