Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

George David Batty; Qing Li; Rachel Huxley; Sophia Zoungas; Barbara Taylor; Bruce Neal; Bastiaan E de Galan; M Woodward; Stephen B Harrap; Stephen Colagiuri; Anushka Patel; John P Chalmers

doi:10.1016/j.eurpsy.2011.07.005

Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

George David Batty, Qing Li, Rachel Huxley, Sophia Zoungas, Barbara Taylor, Bruce Neal, Bastiaan E de Galan, M Woodward, Stephen B Harrap, Stephen Colagiuri, Anushka Patel, John P Chalmers

Monash Centre for Health Research and Implementation

Research output: Contribution to journal › Article › Research › peer-review

64 Citations (Scopus)

Abstract

Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55?88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95 confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.

Original language	English
Pages (from-to)	49 - 52
Number of pages	4
Journal	European Psychiatry
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.eurpsy.2011.07.005
Publication status	Published - 2013

Access to Document

10.1016/j.eurpsy.2011.07.005

RM sElocation

Cite this

Batty, G. D., Li, Q., Huxley, R., Zoungas, S., Taylor, B., Neal, B., de Galan, B. E., Woodward, M., Harrap, S. B., Colagiuri, S., Patel, A., & Chalmers, J. P. (2013). Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial. European Psychiatry, 28(1), 49 - 52. https://doi.org/10.1016/j.eurpsy.2011.07.005

Batty, George David ; Li, Qing ; Huxley, Rachel ; Zoungas, Sophia ; Taylor, Barbara ; Neal, Bruce ; de Galan, Bastiaan E ; Woodward, M ; Harrap, Stephen B ; Colagiuri, Stephen ; Patel, Anushka ; Chalmers, John P. / Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial. In: European Psychiatry. 2013 ; Vol. 28, No. 1. pp. 49 - 52.

@article{ad766c0a3ad04e0b92fa40334bc0b7a7,

title = "Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial",

abstract = "Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55?88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95 confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.",

author = "Batty, {George David} and Qing Li and Rachel Huxley and Sophia Zoungas and Barbara Taylor and Bruce Neal and {de Galan}, {Bastiaan E} and M Woodward and Harrap, {Stephen B} and Stephen Colagiuri and Anushka Patel and Chalmers, {John P}",

year = "2013",

doi = "10.1016/j.eurpsy.2011.07.005",

language = "English",

volume = "28",

pages = "49 -- 52",

journal = "European Psychiatry",

issn = "0924-9338",

publisher = "Elsevier",

number = "1",

}

Batty, GD, Li, Q, Huxley, R, Zoungas, S, Taylor, B, Neal, B, de Galan, BE, Woodward, M, Harrap, SB, Colagiuri, S, Patel, A & Chalmers, JP 2013, 'Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial', European Psychiatry, vol. 28, no. 1, pp. 49 - 52. https://doi.org/10.1016/j.eurpsy.2011.07.005

Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial. / Batty, George David; Li, Qing; Huxley, Rachel; Zoungas, Sophia; Taylor, Barbara; Neal, Bruce; de Galan, Bastiaan E; Woodward, M; Harrap, Stephen B; Colagiuri, Stephen; Patel, Anushka; Chalmers, John P.

In: European Psychiatry, Vol. 28, No. 1, 2013, p. 49 - 52.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

AU - Batty, George David

AU - Li, Qing

AU - Huxley, Rachel

AU - Zoungas, Sophia

AU - Taylor, Barbara

AU - Neal, Bruce

AU - de Galan, Bastiaan E

AU - Woodward, M

AU - Harrap, Stephen B

AU - Colagiuri, Stephen

AU - Patel, Anushka

AU - Chalmers, John P

PY - 2013

Y1 - 2013

N2 - Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55?88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95 confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.

AB - Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. Methods: A total of 11,140 men and women aged 55?88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95 confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.

UR - http://www.sciencedirect.com.ezproxy.lib.monash.edu.au/science/article/pii/S0924933811001246#

U2 - 10.1016/j.eurpsy.2011.07.005

DO - 10.1016/j.eurpsy.2011.07.005

M3 - Article

VL - 28

SP - 49

EP - 52

JO - European Psychiatry

JF - European Psychiatry

SN - 0924-9338

IS - 1

ER -

Batty GD, Li Q, Huxley R, Zoungas S, Taylor B, Neal B et al. Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial. European Psychiatry. 2013;28(1):49 - 52. https://doi.org/10.1016/j.eurpsy.2011.07.005