Optimizing drug dosing in the ICU

X. Liu, P. Kruger, M. S. Roberts

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2 Citations (Scopus)


Patients admitted to the intensive care unit (ICU) may exhibit multiple organ dysfunctions and usually require treatment with a wide range of drugs such as sedatives, analgesics, neuromuscular blockers, and antimicrobials [1]. Recommendations for the dosing regimens in ICU patients are often extrapolated from clinical trials in healthy volunteers or non-ICU patients. This extrapolation assumes similar drug behavior (pharmacokinetics and pharmacodynamics) among ICU and other patients or healthy volunteers. However, it is well described that many drugs used in critically ill patients may have alterations of the pharmacokinetic and pharmacodynamic properties due to pathophysiological changes or drug interactions [1-4]. These changes may occur even within a single patient at varying stages of their illness and, therefore, critically ill patients offer unique challenges in drug dosing.

Original languageEnglish
Title of host publicationYearbook of Intensive Care and Emergency Medicine 2009
Number of pages11
ISBN (Print)9780387922775
Publication statusPublished - 1 Dec 2007
Externally publishedYes

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