Optimization of TCR transgenic T cells for in vivo tracking of immune responses

Angus T. Stock, Scott N. Mueller, Lauren M. Kleinert, William R. Heath, Francis R. Carbone, Claerwen M. Jones

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

T-cell receptor (TCR) transgenic mice have proven useful for the study of various immune parameters. Despite this, it has been suggested that transferred T cells respond differently to their endogenous counterparts at least in terms of conversion to antigen-experienced populations bearing memory cell markers. Here, we have compared the response of TCR transgenic T cells to endogenous populations within the context of infection with herpes simplex virus. We found that adoptive transfer at numbers approaching those of the endogenous virus-specific subset results in a response with similar kinetics, magnitude and memory subset conversion. This suggests that this form of optimized T-cell transfer remains a useful means of tracking antiviral immune responses.

Original languageEnglish
Pages (from-to)394-396
Number of pages3
JournalImmunology and Cell Biology
Volume85
Issue number5
DOIs
Publication statusPublished - 1 Jul 2007
Externally publishedYes

Keywords

  • Memory
  • T cells
  • Transgenic mice

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