Optimization of aqueous SI-ATRP grafting of poly(oligo(ethylene glycol) methacrylate) brushes from benzyl chloride macroinitiator surfaces

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Poly(oligo(ethylene glycol) methacrylate) (pOEGMA) brushes were grafted via surface-initiated atom transfer radical polymerization (SI-ATRP) from a poly(styrene-co-vinylbenzyl chloride) macroinitiator. While bromoisobutyryl initiator groups are most commonly used for this purpose, benzyl chloride initiators may be advantageous for some applications due to superior stability. Water-only graft solutions produced thicker brush coatings with superior low fouling properties (low protein adsorption and cell adhesion) versus mixed water/alcohol solutions. Coatings produced using 475 Da OEGMA (methyl ether terminated) further reduced non-specific interactions compared to 360 Da OEGMA (hydroxyl terminated). Initiator density had minimal effect on low fouling properties.
Original languageEnglish
Pages (from-to)799 - 811
Number of pages13
JournalMacromolecular Bioscience
Volume15
Issue number6
DOIs
Publication statusPublished - 2015

Cite this

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title = "Optimization of aqueous SI-ATRP grafting of poly(oligo(ethylene glycol) methacrylate) brushes from benzyl chloride macroinitiator surfaces",
abstract = "Poly(oligo(ethylene glycol) methacrylate) (pOEGMA) brushes were grafted via surface-initiated atom transfer radical polymerization (SI-ATRP) from a poly(styrene-co-vinylbenzyl chloride) macroinitiator. While bromoisobutyryl initiator groups are most commonly used for this purpose, benzyl chloride initiators may be advantageous for some applications due to superior stability. Water-only graft solutions produced thicker brush coatings with superior low fouling properties (low protein adsorption and cell adhesion) versus mixed water/alcohol solutions. Coatings produced using 475 Da OEGMA (methyl ether terminated) further reduced non-specific interactions compared to 360 Da OEGMA (hydroxyl terminated). Initiator density had minimal effect on low fouling properties.",
author = "Rodda, {Andrew E.} and Francesca Ercole and Nisbet, {David R.} and Forsythe, {John S.} and Laurence Meagher",
year = "2015",
doi = "10.1002/mabi.201400512",
language = "English",
volume = "15",
pages = "799 -- 811",
journal = "Macromolecular Bioscience",
issn = "1616-5187",
publisher = "Wiley-VCH Verlag GmbH & Co. KGaA",
number = "6",

}

TY - JOUR

T1 - Optimization of aqueous SI-ATRP grafting of poly(oligo(ethylene glycol) methacrylate) brushes from benzyl chloride macroinitiator surfaces

AU - Rodda, Andrew E.

AU - Ercole, Francesca

AU - Nisbet, David R.

AU - Forsythe, John S.

AU - Meagher, Laurence

PY - 2015

Y1 - 2015

N2 - Poly(oligo(ethylene glycol) methacrylate) (pOEGMA) brushes were grafted via surface-initiated atom transfer radical polymerization (SI-ATRP) from a poly(styrene-co-vinylbenzyl chloride) macroinitiator. While bromoisobutyryl initiator groups are most commonly used for this purpose, benzyl chloride initiators may be advantageous for some applications due to superior stability. Water-only graft solutions produced thicker brush coatings with superior low fouling properties (low protein adsorption and cell adhesion) versus mixed water/alcohol solutions. Coatings produced using 475 Da OEGMA (methyl ether terminated) further reduced non-specific interactions compared to 360 Da OEGMA (hydroxyl terminated). Initiator density had minimal effect on low fouling properties.

AB - Poly(oligo(ethylene glycol) methacrylate) (pOEGMA) brushes were grafted via surface-initiated atom transfer radical polymerization (SI-ATRP) from a poly(styrene-co-vinylbenzyl chloride) macroinitiator. While bromoisobutyryl initiator groups are most commonly used for this purpose, benzyl chloride initiators may be advantageous for some applications due to superior stability. Water-only graft solutions produced thicker brush coatings with superior low fouling properties (low protein adsorption and cell adhesion) versus mixed water/alcohol solutions. Coatings produced using 475 Da OEGMA (methyl ether terminated) further reduced non-specific interactions compared to 360 Da OEGMA (hydroxyl terminated). Initiator density had minimal effect on low fouling properties.

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U2 - 10.1002/mabi.201400512

DO - 10.1002/mabi.201400512

M3 - Article

VL - 15

SP - 799

EP - 811

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

SN - 1616-5187

IS - 6

ER -