Optimization and evaluation of piperacillin-tobramycin combination dosage regimens against Pseudomonas aeruginosa for patients with altered pharmacokinetics via the hollow-fiber infection model and mechanism-based modeling

Rajbharan Yadav, Kate E. Rogers, Phillip J. Bergen, Jürgen B. Bulitta, Carl M.J. Kirkpatrick, Steven C. Wallis, David L. Paterson, Roger L. Nation, Jeffrey Lipman, Jason A. Roberts, Cornelia B. Landersdorfer

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