Optical tweezers-based immunosensor detects femtomolar concentrations of antigens

Kristian Helmerson, Rani Kishore, William D. Phillips, Howard H. Weetall

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)


We used optical tweezers (optical trapping technology) to measure the force required to separate antigen-antibody bonds. Under competitive-binding conditions, we used the force determination to detect and measure protein antigen concentrations as small as 1 fmol/L (10-15 mol/L).

Original languageEnglish
Pages (from-to)379-383
Number of pages5
JournalClinical Chemistry
Issue number2
Publication statusPublished - 20 Feb 1997
Externally publishedYes


  • antigen-antibody binding
  • imimunoassays
  • lasers

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