Optical manipulation and fusion of liposomes as microreactors

Simone Kulin, Rani Kishore, Kristian Helmerson, Laurie Locascio

Research output: Contribution to journalArticleResearchpeer-review

83 Citations (Scopus)


We present an all-optical method to manipulate and fuse giant liposomes, typically 10 μm in diameter. Optical tweezers are used to trap two individual liposomes, which are then brought into contact. A single pulse of ultraviolet laser light focused on the adjoining membranes induces the fusion between the liposomes. As a consequence, the chemical reagents encapsulated in the two liposomes mix and a chemical reaction takes place.

Original languageEnglish
Pages (from-to)8206-8210
Number of pages5
Issue number20
Publication statusPublished - 30 Sep 2003
Externally publishedYes

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