Optical imaging of electrically evoked visual signals in cats

II. ICA "harmonic filtering" noise reduction.

Spencer C. Chen, Yan T. Wong, Luke E. Hallum, Norbert B. Dommel, Shaun L. Cloherty, John W. Morley, Gregg J. Suaning, Nigel H. Lovell

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

6 Citations (Scopus)

Abstract

Optical imaging of intrinsic signals (OIS) is a tool for visualizing differential areas in the primary visual cortex devoted to visual functions such as ocular dominance and spatial orientation preferences. The OIS methodology was employed to verify visual cortical response to a retinal vision prosthesis whereby electrical stimulation is applied to the neural retina in order to elicit visual percepts. However, OIS recording is quite susceptible to cardiac and respiratory artifact, and inherent noise related to the measurement process. This complicates the identification of evoked signals using standard ensemble averaging based image processing. We therefore developed an independent component analysis (ICA) "harmonic filtering" technique to improve the signal-to-noise ratio. This technique is capable of reducing noise components, highlighting response signals to visual and electrical stimuli. Particularly, we demonstrated extraction of an ocular dominance map due to corneal stimulation and localized cortical activation due to intravitreal stimulation.

Original languageEnglish
Title of host publication2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16
Pages3380-3383
Number of pages4
DOIs
Publication statusPublished - 2007
Externally publishedYes

Publication series

NamePROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY

Cite this

Chen, S. C., Wong, Y. T., Hallum, L. E., Dommel, N. B., Cloherty, S. L., Morley, J. W., ... Lovell, N. H. (2007). Optical imaging of electrically evoked visual signals in cats: II. ICA "harmonic filtering" noise reduction. In 2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16 (pp. 3380-3383). (PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY). Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference https://doi.org/10.1109/IEMBS.2007.4353056
Chen, Spencer C. ; Wong, Yan T. ; Hallum, Luke E. ; Dommel, Norbert B. ; Cloherty, Shaun L. ; Morley, John W. ; Suaning, Gregg J. ; Lovell, Nigel H. / Optical imaging of electrically evoked visual signals in cats : II. ICA "harmonic filtering" noise reduction. 2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16. 2007. pp. 3380-3383 (PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY). (Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference).
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title = "Optical imaging of electrically evoked visual signals in cats: II. ICA {"}harmonic filtering{"} noise reduction.",
abstract = "Optical imaging of intrinsic signals (OIS) is a tool for visualizing differential areas in the primary visual cortex devoted to visual functions such as ocular dominance and spatial orientation preferences. The OIS methodology was employed to verify visual cortical response to a retinal vision prosthesis whereby electrical stimulation is applied to the neural retina in order to elicit visual percepts. However, OIS recording is quite susceptible to cardiac and respiratory artifact, and inherent noise related to the measurement process. This complicates the identification of evoked signals using standard ensemble averaging based image processing. We therefore developed an independent component analysis (ICA) {"}harmonic filtering{"} technique to improve the signal-to-noise ratio. This technique is capable of reducing noise components, highlighting response signals to visual and electrical stimuli. Particularly, we demonstrated extraction of an ocular dominance map due to corneal stimulation and localized cortical activation due to intravitreal stimulation.",
author = "Chen, {Spencer C.} and Wong, {Yan T.} and Hallum, {Luke E.} and Dommel, {Norbert B.} and Cloherty, {Shaun L.} and Morley, {John W.} and Suaning, {Gregg J.} and Lovell, {Nigel H.}",
note = "29th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society, Lyon, FRANCE, AUG 22-26, 2007",
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Chen, SC, Wong, YT, Hallum, LE, Dommel, NB, Cloherty, SL, Morley, JW, Suaning, GJ & Lovell, NH 2007, Optical imaging of electrically evoked visual signals in cats: II. ICA "harmonic filtering" noise reduction. in 2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16. PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, pp. 3380-3383. https://doi.org/10.1109/IEMBS.2007.4353056

Optical imaging of electrically evoked visual signals in cats : II. ICA "harmonic filtering" noise reduction. / Chen, Spencer C.; Wong, Yan T.; Hallum, Luke E.; Dommel, Norbert B.; Cloherty, Shaun L.; Morley, John W.; Suaning, Gregg J.; Lovell, Nigel H.

2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16. 2007. p. 3380-3383 (PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY), (Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

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AU - Chen, Spencer C.

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AU - Hallum, Luke E.

AU - Dommel, Norbert B.

AU - Cloherty, Shaun L.

AU - Morley, John W.

AU - Suaning, Gregg J.

AU - Lovell, Nigel H.

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AB - Optical imaging of intrinsic signals (OIS) is a tool for visualizing differential areas in the primary visual cortex devoted to visual functions such as ocular dominance and spatial orientation preferences. The OIS methodology was employed to verify visual cortical response to a retinal vision prosthesis whereby electrical stimulation is applied to the neural retina in order to elicit visual percepts. However, OIS recording is quite susceptible to cardiac and respiratory artifact, and inherent noise related to the measurement process. This complicates the identification of evoked signals using standard ensemble averaging based image processing. We therefore developed an independent component analysis (ICA) "harmonic filtering" technique to improve the signal-to-noise ratio. This technique is capable of reducing noise components, highlighting response signals to visual and electrical stimuli. Particularly, we demonstrated extraction of an ocular dominance map due to corneal stimulation and localized cortical activation due to intravitreal stimulation.

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Chen SC, Wong YT, Hallum LE, Dommel NB, Cloherty SL, Morley JW et al. Optical imaging of electrically evoked visual signals in cats: II. ICA "harmonic filtering" noise reduction. In 2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16. 2007. p. 3380-3383. (PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY). (Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference). https://doi.org/10.1109/IEMBS.2007.4353056