Abstract
Optical imaging of intrinsic signals (OIS) is a tool for visualizing differential areas in the primary visual cortex devoted to visual functions such as ocular dominance and spatial orientation preferences. The OIS methodology was employed to verify visual cortical response to a retinal vision prosthesis whereby electrical stimulation is applied to the neural retina in order to elicit visual percepts. However, OIS recording is quite susceptible to cardiac and respiratory artifact, and inherent noise related to the measurement process. This complicates the identification of evoked signals using standard ensemble averaging based image processing. We therefore developed an independent component analysis (ICA) "harmonic filtering" technique to improve the signal-to-noise ratio. This technique is capable of reducing noise components, highlighting response signals to visual and electrical stimuli. Particularly, we demonstrated extraction of an ocular dominance map due to corneal stimulation and localized cortical activation due to intravitreal stimulation.
Original language | English |
---|---|
Title of host publication | Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2007 |
Pages | 3380-3383 |
Number of pages | 4 |
DOIs | |
Publication status | Published - 2007 |
Externally published | Yes |
Event | International Conference of the IEEE Engineering in Medicine and Biology Society 2007 - Centre de Congres, Lyon, France Duration: 22 Aug 2007 → 26 Aug 2007 Conference number: 29th |
Conference
Conference | International Conference of the IEEE Engineering in Medicine and Biology Society 2007 |
---|---|
Abbreviated title | EMBC 2007 |
Country | France |
City | Lyon |
Period | 22/08/07 → 26/08/07 |
Other | in conjunction with the Biennial Conference of the French society of Biological and Medical Engineering (SFGBM) |