Abstract
Optical imaging of intrinsic signals (OIS) is a tool for visualizing differential areas in the primary visual cortex devoted to visual functions such as ocular dominance and spatial orientation preferences. The OIS methodology was employed to verify visual cortical response to a retinal vision prosthesis whereby electrical stimulation is applied to the neural retina in order to elicit visual percepts. However, OIS recording is quite susceptible to cardiac and respiratory artifact, and inherent noise related to the measurement process. This complicates the identification of evoked signals using standard ensemble averaging based image processing. We therefore developed an independent component analysis (ICA) "harmonic filtering" technique to improve the signal-to-noise ratio. This technique is capable of reducing noise components, highlighting response signals to visual and electrical stimuli. Particularly, we demonstrated extraction of an ocular dominance map due to corneal stimulation and localized cortical activation due to intravitreal stimulation.
| Original language | English |
|---|---|
| Title of host publication | 2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16 |
| Pages | 3380-3383 |
| Number of pages | 4 |
| DOIs | |
| Publication status | Published - 2007 |
| Externally published | Yes |
Publication series
| Name | PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY |
|---|
Cite this
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Optical imaging of electrically evoked visual signals in cats : II. ICA "harmonic filtering" noise reduction. / Chen, Spencer C.; Wong, Yan T.; Hallum, Luke E.; Dommel, Norbert B.; Cloherty, Shaun L.; Morley, John W.; Suaning, Gregg J.; Lovell, Nigel H.
2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16. 2007. p. 3380-3383 (PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY), (Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference).Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review
TY - GEN
T1 - Optical imaging of electrically evoked visual signals in cats
T2 - II. ICA "harmonic filtering" noise reduction.
AU - Chen, Spencer C.
AU - Wong, Yan T.
AU - Hallum, Luke E.
AU - Dommel, Norbert B.
AU - Cloherty, Shaun L.
AU - Morley, John W.
AU - Suaning, Gregg J.
AU - Lovell, Nigel H.
N1 - 29th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society, Lyon, FRANCE, AUG 22-26, 2007
PY - 2007
Y1 - 2007
N2 - Optical imaging of intrinsic signals (OIS) is a tool for visualizing differential areas in the primary visual cortex devoted to visual functions such as ocular dominance and spatial orientation preferences. The OIS methodology was employed to verify visual cortical response to a retinal vision prosthesis whereby electrical stimulation is applied to the neural retina in order to elicit visual percepts. However, OIS recording is quite susceptible to cardiac and respiratory artifact, and inherent noise related to the measurement process. This complicates the identification of evoked signals using standard ensemble averaging based image processing. We therefore developed an independent component analysis (ICA) "harmonic filtering" technique to improve the signal-to-noise ratio. This technique is capable of reducing noise components, highlighting response signals to visual and electrical stimuli. Particularly, we demonstrated extraction of an ocular dominance map due to corneal stimulation and localized cortical activation due to intravitreal stimulation.
AB - Optical imaging of intrinsic signals (OIS) is a tool for visualizing differential areas in the primary visual cortex devoted to visual functions such as ocular dominance and spatial orientation preferences. The OIS methodology was employed to verify visual cortical response to a retinal vision prosthesis whereby electrical stimulation is applied to the neural retina in order to elicit visual percepts. However, OIS recording is quite susceptible to cardiac and respiratory artifact, and inherent noise related to the measurement process. This complicates the identification of evoked signals using standard ensemble averaging based image processing. We therefore developed an independent component analysis (ICA) "harmonic filtering" technique to improve the signal-to-noise ratio. This technique is capable of reducing noise components, highlighting response signals to visual and electrical stimuli. Particularly, we demonstrated extraction of an ocular dominance map due to corneal stimulation and localized cortical activation due to intravitreal stimulation.
UR - http://www.scopus.com/inward/record.url?scp=84903864780&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2007.4353056
DO - 10.1109/IEMBS.2007.4353056
M3 - Conference Paper
SN - 9781424407873
T3 - PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY
SP - 3380
EP - 3383
BT - 2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16
ER -