Opioids for the palliation of breathlessness Cochrane review: dditional analyses yield same conclusions

We thank Associate Professor Magnus Ekström et al for their research letter regarding our Cochrane Review: Opioids for the palliation of refractory breathlessness in adults with advanced disease and terminal illness (1,2). We also acknowledge that following the publication of their letter in Thorax, feedback was provided through the appropriate mechanism to the Cochrane Review Group (2). We have published a detailed response to their comments in the feedback section of our review, however, given the seriousness of the criticisms published in Thorax, we think it is important that our response also sit alongside their Thorax letter.