Opioid receptor modulation of hedonic taste preference and food intake: A single-dose safety, pharmacokinetic, and pharmacodynamic investigation with GSK1521498, a novel μ-opioid receptor inverse agonist

Pradeep J. Nathan, Barry V. O'Neill, Mark A Bush, Annelize Koch, Wenli X. Tao, Kay Maltby, Antonella Napolitano, Allison C. Brooke, Andrew L Skeggs, Craig S. Herman, Andrew L. Larkin, Diane M. Ignar, Duncan B Richards, Pauline M. Williams, Edward T. Bullmore

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36 Citations (Scopus)

Abstract

Endogenous opioids and μ-opioid receptors have been linked to hedonic and rewarding aspects of palatable food intake. The authors examined the safety, pharmacokinetic, and pharmacodynamic profile of GSK1521498, a μ-opioid receptor inverse agonist that is being investigated primarily for the treatment of overeating behavior in obesity. In healthy participants, GSK1521498 oral solution and capsule formulations were well tolerated up to a dose of 100 mg. After single doses (10-150 mg), the maximum concentration (Cmax) and area under the curve (AUC) in plasma increased in a dose-proportional manner. GSK1521498 selectively reduced sensory hedonic ratings of high-sugar and high-fat dairy products and caloric intake of high-fat/high-sucrose snack foods. These findings provide encouraging data in support of the development of GSK1521498 for the treatment of disorders of maladaptive ingestive behavior or compulsive consumption.

Original languageEnglish
Pages (from-to)464-474
Number of pages11
JournalThe Journal of Clinical Pharmacology
Volume52
Issue number4
DOIs
Publication statusPublished - Apr 2012
Externally publishedYes

Keywords

  • μ-Opioid receptor
  • binge eating
  • food intake
  • hedonic
  • obesity
  • pharmacodynamic
  • pharmacokinetics
  • reward
  • taste preference

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