Opioid pharmacology under the microscope

Damien Jullié, Arisbel B. Gondin, Mark Von Zastrow, Meritxell Canals

Research output: Contribution to journalReview ArticleOtherpeer-review

7 Citations (Scopus)

Abstract

The powerful analgesic effects of opioid drugs have captivated the interest of physicians and scientists for millennia, and the ability of opioid drugs to produce serious undesired effects has been recognized for a similar period of time (Kieffer and Evans, 2009). Many of these develop progressively with prolonged or repeated drug use and then persist, motivating particular interest in understanding how opioid drugs initiate adaptive or maladaptive modifications in neural function or regulation. Exciting advances have been made over the past several years in elucidating drug-induced changes at molecular, cellular, and physiologic scales of analysis. The present review will highlight some recent cellular studies that we believe bridge across scales and will focus on optical imaging approaches that put opioid drug action "under the microscope."

Original languageEnglish
Pages (from-to)425-432
Number of pages8
JournalMolecular Pharmacology
Volume98
Issue number4
DOIs
Publication statusPublished - Oct 2020

Keywords

  • pharmacology
  • opioid receptor
  • GPCR (G-protein-coupled receptor)
  • microscopy

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