OPIOID BIOLOGY

THE NEXT SET OF QUESTIONS

    Research output: Contribution to journalArticleResearchpeer-review

    2 Citations (Scopus)

    Abstract

    Abstract: :A range of biologically different opioid peptides are synthesised as components of three distinct precursors, pro‐opiomelanocortin, proenkephalin, and prodynorphin. They interact with a number of receptors which have so far been characterised as mu, delta, kappa, sigma, and epsilon. It is unclear which ligands bind to which receptors under physiological circumstances, but preferential in vitro interactions include enkephalins with delta receptors, dynorphin with kappa receptors, and /?‐endorphin with epsilon receptors. Post‐translational processing determines which of several opioid products are produced from each precursor, but the identity of the enzymes involved and regulation of processing is unknown. Opioid involvement in the neuroendocrine and cardiovascular systems is reviewed. Naloxone‐sensitive opioid mechanisms are implicated in the control of gonadotrophin and adrenocorticotropic hormone secretion and in the hypotension of various types of shock. The investigation of possible dynorphin involvement in neurohypophysial function is taking place because vasopressin and dynorphin A (1–8) have been shown to coexist in the neurosecretory vesicles of magnocellular neurons.

    Original languageEnglish
    Pages (from-to)98-106
    Number of pages9
    JournalAustralian and New Zealand Journal of Medicine
    Volume15
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 1985

    Keywords

    • dynorphins
    • endorphins
    • Enkephalins
    • naloxone.
    • opioid precursors
    • opioid receptors
    • post‐translational processing

    Cite this

    @article{3251eabfdf1242c7b808a82846012818,
    title = "OPIOID BIOLOGY: THE NEXT SET OF QUESTIONS",
    abstract = "Abstract: :A range of biologically different opioid peptides are synthesised as components of three distinct precursors, pro‐opiomelanocortin, proenkephalin, and prodynorphin. They interact with a number of receptors which have so far been characterised as mu, delta, kappa, sigma, and epsilon. It is unclear which ligands bind to which receptors under physiological circumstances, but preferential in vitro interactions include enkephalins with delta receptors, dynorphin with kappa receptors, and /?‐endorphin with epsilon receptors. Post‐translational processing determines which of several opioid products are produced from each precursor, but the identity of the enzymes involved and regulation of processing is unknown. Opioid involvement in the neuroendocrine and cardiovascular systems is reviewed. Naloxone‐sensitive opioid mechanisms are implicated in the control of gonadotrophin and adrenocorticotropic hormone secretion and in the hypotension of various types of shock. The investigation of possible dynorphin involvement in neurohypophysial function is taking place because vasopressin and dynorphin A (1–8) have been shown to coexist in the neurosecretory vesicles of magnocellular neurons.",
    keywords = "dynorphins, endorphins, Enkephalins, naloxone., opioid precursors, opioid receptors, post‐translational processing",
    author = "COPOLOV, {D. L.}",
    year = "1985",
    month = "1",
    day = "1",
    doi = "10.1111/j.1445-5994.1985.tb02757.x",
    language = "English",
    volume = "15",
    pages = "98--106",
    journal = "Internal Medicine Journal",
    issn = "1444-0903",
    publisher = "Wiley-Blackwell",
    number = "1",

    }

    OPIOID BIOLOGY : THE NEXT SET OF QUESTIONS. / COPOLOV, D. L.

    In: Australian and New Zealand Journal of Medicine, Vol. 15, No. 1, 01.01.1985, p. 98-106.

    Research output: Contribution to journalArticleResearchpeer-review

    TY - JOUR

    T1 - OPIOID BIOLOGY

    T2 - THE NEXT SET OF QUESTIONS

    AU - COPOLOV, D. L.

    PY - 1985/1/1

    Y1 - 1985/1/1

    N2 - Abstract: :A range of biologically different opioid peptides are synthesised as components of three distinct precursors, pro‐opiomelanocortin, proenkephalin, and prodynorphin. They interact with a number of receptors which have so far been characterised as mu, delta, kappa, sigma, and epsilon. It is unclear which ligands bind to which receptors under physiological circumstances, but preferential in vitro interactions include enkephalins with delta receptors, dynorphin with kappa receptors, and /?‐endorphin with epsilon receptors. Post‐translational processing determines which of several opioid products are produced from each precursor, but the identity of the enzymes involved and regulation of processing is unknown. Opioid involvement in the neuroendocrine and cardiovascular systems is reviewed. Naloxone‐sensitive opioid mechanisms are implicated in the control of gonadotrophin and adrenocorticotropic hormone secretion and in the hypotension of various types of shock. The investigation of possible dynorphin involvement in neurohypophysial function is taking place because vasopressin and dynorphin A (1–8) have been shown to coexist in the neurosecretory vesicles of magnocellular neurons.

    AB - Abstract: :A range of biologically different opioid peptides are synthesised as components of three distinct precursors, pro‐opiomelanocortin, proenkephalin, and prodynorphin. They interact with a number of receptors which have so far been characterised as mu, delta, kappa, sigma, and epsilon. It is unclear which ligands bind to which receptors under physiological circumstances, but preferential in vitro interactions include enkephalins with delta receptors, dynorphin with kappa receptors, and /?‐endorphin with epsilon receptors. Post‐translational processing determines which of several opioid products are produced from each precursor, but the identity of the enzymes involved and regulation of processing is unknown. Opioid involvement in the neuroendocrine and cardiovascular systems is reviewed. Naloxone‐sensitive opioid mechanisms are implicated in the control of gonadotrophin and adrenocorticotropic hormone secretion and in the hypotension of various types of shock. The investigation of possible dynorphin involvement in neurohypophysial function is taking place because vasopressin and dynorphin A (1–8) have been shown to coexist in the neurosecretory vesicles of magnocellular neurons.

    KW - dynorphins

    KW - endorphins

    KW - Enkephalins

    KW - naloxone.

    KW - opioid precursors

    KW - opioid receptors

    KW - post‐translational processing

    UR - http://www.scopus.com/inward/record.url?scp=0021887808&partnerID=8YFLogxK

    U2 - 10.1111/j.1445-5994.1985.tb02757.x

    DO - 10.1111/j.1445-5994.1985.tb02757.x

    M3 - Article

    VL - 15

    SP - 98

    EP - 106

    JO - Internal Medicine Journal

    JF - Internal Medicine Journal

    SN - 1444-0903

    IS - 1

    ER -