Opinion: Chemokines: More than just road signs

Martin F. Bachmann, Manfred Kopf, Benjamin J. Marsland

Research output: Contribution to journalReview ArticleResearchpeer-review

113 Citations (Scopus)

Abstract

Chemokines have long been known to orchestrate dendritic-cell migration in the body. However, recent evidence has shown that chemokines not only direct the trafficking of dendritic cells but also can regulate their maturation status. Here, we propose that this dual function of chemokines ensures that T cells and dendritic cells meet in T-cell regions of lymphoid organs and that antigen is presented in an immunologically optimal context for T-cell priming.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalNature Reviews Immunology
Volume6
Issue number2
DOIs
Publication statusPublished - 1 Feb 2006
Externally publishedYes

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