Open-label study of absorption and clearance of 1% voriconazole eye drops

Chin Fen Neoh; Lok Leung; Elsie Chan; Daoud Al-Badriyeh; Robert O. Fullinfaw; Vishal Jhanji; Rasik B. Vajpayee; Geoffrey E Davies; Kay Stewart; David C.M. Kong

doi:10.1128/AAC.00683-16

Open-label study of absorption and clearance of 1% voriconazole eye drops

Chin Fen Neoh
, Lok Leung
, Elsie Chan
, Daoud Al-Badriyeh
, Robert O. Fullinfaw
, Vishal Jhanji
, Rasik B. Vajpayee
, Geoffrey E Davies
, Kay Stewart
, David C.M. Kong

Centre for Medicine Use and Safety

Research output: Contribution to journal › Article › Other › peer-review

12 Citations (Scopus)

Abstract

Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC90 values for typical fungi that cause keratitis.

Original language	English
Pages (from-to)	6896-6898
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	11
DOIs	https://doi.org/10.1128/AAC.00683-16
Publication status	Published - 1 Nov 2016

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1128/AAC.00683-16

Cite this

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title = "Open-label study of absorption and clearance of 1\% voriconazole eye drops",

abstract = "Twenty participants undergoing elective cataract surgery received 1\% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC90 values for typical fungi that cause keratitis.",

author = "Neoh, \{Chin Fen\} and Lok Leung and Elsie Chan and Daoud Al-Badriyeh and Fullinfaw, \{Robert O.\} and Vishal Jhanji and Vajpayee, \{Rasik B.\} and Davies, \{Geoffrey E\} and Kay Stewart and Kong, \{David C.M.\}",

year = "2016",

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doi = "10.1128/AAC.00683-16",

language = "English",

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TY - JOUR

T1 - Open-label study of absorption and clearance of 1% voriconazole eye drops

AU - Neoh, Chin Fen

AU - Leung, Lok

AU - Chan, Elsie

AU - Al-Badriyeh, Daoud

AU - Fullinfaw, Robert O.

AU - Jhanji, Vishal

AU - Vajpayee, Rasik B.

AU - Davies, Geoffrey E

AU - Stewart, Kay

AU - Kong, David C.M.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC90 values for typical fungi that cause keratitis.

AB - Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC90 values for typical fungi that cause keratitis.

UR - https://www.scopus.com/pages/publications/84994525872

U2 - 10.1128/AAC.00683-16

DO - 10.1128/AAC.00683-16

M3 - Article

C2 - 27550348

AN - SCOPUS:84994525872

SN - 0066-4804

VL - 60

SP - 6896

EP - 6898

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

Open-label study of absorption and clearance of 1% voriconazole eye drops

Abstract

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