Open access resource for cellular-resolution analyses of corticocortical connectivity in the marmoset monkey

Piotr Majka, Shi Bai, Sophia Bakola, Sylwia Bednarek, Jonathan M. Chan, Natalia Jermakow, Lauretta Passarelli, David H. Reser, Panagiota Theodoni, Katrina H. Worthy, Xiao Jing Wang, Daniel K. Wójcik, Partha P. Mitra, Marcello G.P. Rosa

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Abstract

Understanding the principles of neuronal connectivity requires tools for efficient quantification and visualization of large datasets. The primate cortex is particularly challenging due to its complex mosaic of areas, which in many cases lack clear boundaries. Here, we introduce a resource that allows exploration of results of 143 retrograde tracer injections in the marmoset neocortex. Data obtained in different animals are registered to a common stereotaxic space using an algorithm guided by expert delineation of histological borders, allowing accurate assignment of connections to areas despite interindividual variability. The resource incorporates tools for analyses relative to cytoarchitectural areas, including statistical properties such as the fraction of labeled neurons and the percentage of supragranular neurons. It also provides purely spatial (parcellation-free) data, based on the stereotaxic coordinates of 2 million labeled neurons. This resource helps bridge the gap between high-density cellular connectivity studies in rodents and imaging-based analyses of human brains.

Original languageEnglish
Article number1133
Number of pages14
JournalNature Communications
Volume11
Issue number1
DOIs
Publication statusPublished - 28 Feb 2020

Keywords

  • extrastriate cortex
  • network models

Cite this

Majka, P., Bai, S., Bakola, S., Bednarek, S., Chan, J. M., Jermakow, N., Passarelli, L., Reser, D. H., Theodoni, P., Worthy, K. H., Wang, X. J., Wójcik, D. K., Mitra, P. P., & Rosa, M. G. P. (2020). Open access resource for cellular-resolution analyses of corticocortical connectivity in the marmoset monkey. Nature Communications, 11(1), [1133]. https://doi.org/10.1038/s41467-020-14858-0