Oocyte-specific deletion of pten causes premature activation of the primordial follicle pool

Pradeep Reddy, Lian Liu, Deepak Adhikari, Krishna Jagarlamudi, Singareddy Rajareddy, Yan Shen, Chun Du, Wenli Tang, Tuula Hämäläinen, Stanford L. Peng, Zi Jian Lan, Austin J. Cooney, Ilpo Huhtaniemi, Kui Liu

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Abstract

In the mammalian ovary, progressive activation of primordial follicles from the dormant pool serves as the source of fertilizable ova. Menopause, or the end of female reproductive life, occurs when the primordial follicle pool is exhausted. However, the molecular mechanisms underlying follicle activation are poorly understood. We provide genetic evidence that in mice lacking PTEN (phosphatase and tensin homolog deleted on chromosome 10) in oocytes, a major negative regulator of phosphatidylinositol 3-kinase (PI3K), the entire primordial follicle pool becomes activated. Subsequently, all primordial follicles become depleted in early adulthood, causing premature ovarian failure (POF). Our results show that the mammalian oocyte serves as the headquarters of programming of follicle activation and that the oocyte PTEN-PI3K pathway governs follicle activation through control of initiation of oocyte growth.

Original languageEnglish
Pages (from-to)611-613
Number of pages3
JournalScience
Volume319
Issue number5863
DOIs
Publication statusPublished - 1 Feb 2008
Externally publishedYes

Cite this

Reddy, P., Liu, L., Adhikari, D., Jagarlamudi, K., Rajareddy, S., Shen, Y., Du, C., Tang, W., Hämäläinen, T., Peng, S. L., Lan, Z. J., Cooney, A. J., Huhtaniemi, I., & Liu, K. (2008). Oocyte-specific deletion of pten causes premature activation of the primordial follicle pool. Science, 319(5863), 611-613. https://doi.org/10.1126/science.1152257