Onset of response with duloxetine treatment in patients with osteoarthritis knee pain and chronic low back pain: a post hoc analysis of placebo-controlled trials

Owen Douglas Williamson, Melissa Schroer, Dustin D Ruff, Jonna Ahl, Anthony J Margherita, Doron Sagman, Madelaine M Wohlreich

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13 Citations (Scopus)


Background Knowing when to change pain-medication strategy is not well researched and remains a gap in treating chronic pain. Objective Our aim was to determine how long to treat osteoarthritis (OA) knee pain and chronic low back pain (CLBP) with duloxetine before considering a change in medication strategy. Methods We employed a post hoc analysis of changes in pain-severity data from placebo-controlled studies of duloxetine treatment in nondepressed patients with OA knee pain and CLBP. The studies were selected for inclusion in the analyses based on similarity of study design. Pain severity was recorded daily in patient diaries using an ordinal 11-point numerical rating scale (0 = no pain to 10 = most severe pain). The weekly means of the daily 24-hour average pain severity ratings from these diaries were pooled within disease states. Moderate response was defined as at least a 30 reduction from baseline in pain severity, and minimal improvement was defined as
Original languageEnglish
Pages (from-to)544 - 551
Number of pages8
JournalClinical Therapeutics
Issue number4
Publication statusPublished - 2014

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