One versus two venous anastomoses in microsurgical free flaps: a meta-analysis

Iraj Ahmadi, Pradyumna V Herle, Warren Rozen, James Chin Sek Leong

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background Various reports suggest the augmentation of venous drainage through performing two venous anastomoses as a means of reducing the rate of thrombosis in free flap surgery. However, some suggest dual venous drainage may actually reduce venous blood flow velocity causing a potential risk for thrombosis. Methods On the basis of the Preferred Reporting Items for Systematics Reviews and Meta-analysis statement, a systematic search was conducted using PubMed and Medline databases. A total of 12,190 articles relating to free flaps and one versus two venous anastomoses were found between January 1992 and November 2012. Of the 12,190 articles, 23 studies were included in a meta-analysis performed using STATA 11.2 (StrataCorp, College Station, TX). Studies with case control groups for both single and double venous anastomoses and clearly defined results for flap failure and venous thrombosis were included. 95 confidence interval (CI) were calculated for each study and pooled in both fixed and random-effects models for both flap failure and venous thrombosis events. Results The analysis shows a significant reduction in flap failure (risk ratio, 0.64; 95 CI, 0.41-0.99; p = 0.03) and venous thrombosis (risk ratio, 0.66; 95 CI, 0.46-0.97; p = 0.047) when performing two venous anastomoses compared with one in free flap surgery. Conclusion The results show that performing two venous anastomoses is associated with a reduction in the incidence of flap failure by 36 and venous thrombosis by 34 compared with one venous anastomoses. Given that the performing of an additional venous anastomoses confers a lower risk of complication and is technically feasible, where possible two venous anastomoses should be performed in free flap procedures, however, this should be decided on a flap by flap basis.
Original languageEnglish
Pages (from-to)413 - 417
Number of pages5
JournalJournal of Reconstructive Microsurgery
Volume30
Issue number6
DOIs
Publication statusPublished - 2014

Cite this

@article{8dc0d54c2cbd434899cf5e617e0b0368,
title = "One versus two venous anastomoses in microsurgical free flaps: a meta-analysis",
abstract = "Background Various reports suggest the augmentation of venous drainage through performing two venous anastomoses as a means of reducing the rate of thrombosis in free flap surgery. However, some suggest dual venous drainage may actually reduce venous blood flow velocity causing a potential risk for thrombosis. Methods On the basis of the Preferred Reporting Items for Systematics Reviews and Meta-analysis statement, a systematic search was conducted using PubMed and Medline databases. A total of 12,190 articles relating to free flaps and one versus two venous anastomoses were found between January 1992 and November 2012. Of the 12,190 articles, 23 studies were included in a meta-analysis performed using STATA 11.2 (StrataCorp, College Station, TX). Studies with case control groups for both single and double venous anastomoses and clearly defined results for flap failure and venous thrombosis were included. 95 confidence interval (CI) were calculated for each study and pooled in both fixed and random-effects models for both flap failure and venous thrombosis events. Results The analysis shows a significant reduction in flap failure (risk ratio, 0.64; 95 CI, 0.41-0.99; p = 0.03) and venous thrombosis (risk ratio, 0.66; 95 CI, 0.46-0.97; p = 0.047) when performing two venous anastomoses compared with one in free flap surgery. Conclusion The results show that performing two venous anastomoses is associated with a reduction in the incidence of flap failure by 36 and venous thrombosis by 34 compared with one venous anastomoses. Given that the performing of an additional venous anastomoses confers a lower risk of complication and is technically feasible, where possible two venous anastomoses should be performed in free flap procedures, however, this should be decided on a flap by flap basis.",
author = "Iraj Ahmadi and Herle, {Pradyumna V} and Warren Rozen and Leong, {James Chin Sek}",
year = "2014",
doi = "10.1055/s-0034-1372368",
language = "English",
volume = "30",
pages = "413 -- 417",
journal = "Journal of Reconstructive Microsurgery",
issn = "0743-684X",
publisher = "Thieme Publishing",
number = "6",

}

One versus two venous anastomoses in microsurgical free flaps: a meta-analysis. / Ahmadi, Iraj; Herle, Pradyumna V; Rozen, Warren; Leong, James Chin Sek.

In: Journal of Reconstructive Microsurgery, Vol. 30, No. 6, 2014, p. 413 - 417.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - One versus two venous anastomoses in microsurgical free flaps: a meta-analysis

AU - Ahmadi, Iraj

AU - Herle, Pradyumna V

AU - Rozen, Warren

AU - Leong, James Chin Sek

PY - 2014

Y1 - 2014

N2 - Background Various reports suggest the augmentation of venous drainage through performing two venous anastomoses as a means of reducing the rate of thrombosis in free flap surgery. However, some suggest dual venous drainage may actually reduce venous blood flow velocity causing a potential risk for thrombosis. Methods On the basis of the Preferred Reporting Items for Systematics Reviews and Meta-analysis statement, a systematic search was conducted using PubMed and Medline databases. A total of 12,190 articles relating to free flaps and one versus two venous anastomoses were found between January 1992 and November 2012. Of the 12,190 articles, 23 studies were included in a meta-analysis performed using STATA 11.2 (StrataCorp, College Station, TX). Studies with case control groups for both single and double venous anastomoses and clearly defined results for flap failure and venous thrombosis were included. 95 confidence interval (CI) were calculated for each study and pooled in both fixed and random-effects models for both flap failure and venous thrombosis events. Results The analysis shows a significant reduction in flap failure (risk ratio, 0.64; 95 CI, 0.41-0.99; p = 0.03) and venous thrombosis (risk ratio, 0.66; 95 CI, 0.46-0.97; p = 0.047) when performing two venous anastomoses compared with one in free flap surgery. Conclusion The results show that performing two venous anastomoses is associated with a reduction in the incidence of flap failure by 36 and venous thrombosis by 34 compared with one venous anastomoses. Given that the performing of an additional venous anastomoses confers a lower risk of complication and is technically feasible, where possible two venous anastomoses should be performed in free flap procedures, however, this should be decided on a flap by flap basis.

AB - Background Various reports suggest the augmentation of venous drainage through performing two venous anastomoses as a means of reducing the rate of thrombosis in free flap surgery. However, some suggest dual venous drainage may actually reduce venous blood flow velocity causing a potential risk for thrombosis. Methods On the basis of the Preferred Reporting Items for Systematics Reviews and Meta-analysis statement, a systematic search was conducted using PubMed and Medline databases. A total of 12,190 articles relating to free flaps and one versus two venous anastomoses were found between January 1992 and November 2012. Of the 12,190 articles, 23 studies were included in a meta-analysis performed using STATA 11.2 (StrataCorp, College Station, TX). Studies with case control groups for both single and double venous anastomoses and clearly defined results for flap failure and venous thrombosis were included. 95 confidence interval (CI) were calculated for each study and pooled in both fixed and random-effects models for both flap failure and venous thrombosis events. Results The analysis shows a significant reduction in flap failure (risk ratio, 0.64; 95 CI, 0.41-0.99; p = 0.03) and venous thrombosis (risk ratio, 0.66; 95 CI, 0.46-0.97; p = 0.047) when performing two venous anastomoses compared with one in free flap surgery. Conclusion The results show that performing two venous anastomoses is associated with a reduction in the incidence of flap failure by 36 and venous thrombosis by 34 compared with one venous anastomoses. Given that the performing of an additional venous anastomoses confers a lower risk of complication and is technically feasible, where possible two venous anastomoses should be performed in free flap procedures, however, this should be decided on a flap by flap basis.

UR - http://www.ncbi.nlm.nih.gov/pubmed/24960200

U2 - 10.1055/s-0034-1372368

DO - 10.1055/s-0034-1372368

M3 - Article

VL - 30

SP - 413

EP - 417

JO - Journal of Reconstructive Microsurgery

JF - Journal of Reconstructive Microsurgery

SN - 0743-684X

IS - 6

ER -