One-pot tandem enantioselective hydrogenation-hydroformylation synthesis of cyclic α-amino acids

Euneace Teoh; Eva M. Campi; W. Roy Jackson; Andrea J. Robinson

doi:10.1039/b209087m

One-pot tandem enantioselective hydrogenation-hydroformylation synthesis of cyclic α-amino acids

Euneace Teoh, Eva M. Campi, W. Roy Jackson, Andrea J. Robinson

School of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

25 Citations (Scopus)

Abstract

Five- and six-membered cyclic amino acids can be prepared in good yield with high ee (> 95%) via tandem rhodium-DuPHOS catalysed asymmetric hydrogenation followed by a rhodium-catalysed hydroformylation-cyclisation sequence in a single pot. The synthesis can be achieved using Rh-DuPHOS as the sole catalyst.

Original language	English
Pages (from-to)	387-394
Number of pages	8
Journal	New Journal of Chemistry
Volume	27
Issue number	2
DOIs	https://doi.org/10.1039/b209087m
Publication status	Published - 1 Feb 2003

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abstract = "Five- and six-membered cyclic amino acids can be prepared in good yield with high ee (> 95%) via tandem rhodium-DuPHOS catalysed asymmetric hydrogenation followed by a rhodium-catalysed hydroformylation-cyclisation sequence in a single pot. The synthesis can be achieved using Rh-DuPHOS as the sole catalyst.",

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AU - Teoh, Euneace

AU - Campi, Eva M.

AU - Jackson, W. Roy

AU - Robinson, Andrea J.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Five- and six-membered cyclic amino acids can be prepared in good yield with high ee (> 95%) via tandem rhodium-DuPHOS catalysed asymmetric hydrogenation followed by a rhodium-catalysed hydroformylation-cyclisation sequence in a single pot. The synthesis can be achieved using Rh-DuPHOS as the sole catalyst.

AB - Five- and six-membered cyclic amino acids can be prepared in good yield with high ee (> 95%) via tandem rhodium-DuPHOS catalysed asymmetric hydrogenation followed by a rhodium-catalysed hydroformylation-cyclisation sequence in a single pot. The synthesis can be achieved using Rh-DuPHOS as the sole catalyst.

UR - http://www.scopus.com/inward/record.url?scp=0037296496&partnerID=8YFLogxK

U2 - 10.1039/b209087m

DO - 10.1039/b209087m

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JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 2

ER -

One-pot tandem enantioselective hydrogenation-hydroformylation synthesis of cyclic α-amino acids

Abstract

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