One-pot selective homodimerization/hydrogenation strategy for sequential dicarba bridge formation

James Burnley, William Roy Jackson, Andrea Jane Robinson

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

The installation of interlocked dicarba bridges into peptide sequences requires the development of a regioselective and chemoselective methodology. This manuscript describes a one-pot, chemoselective synthesis of three 2,7-diaminosuberic acid derivatives from an alkyne, a cobalt-carbonyl protected alkyne, and an alkene using metathesis and homogeneous hydrogenation catalysis
Original languageEnglish
Pages (from-to)9057-9063
Number of pages7
JournalThe Journal of Organic Chemistry
Volume80
Issue number18
DOIs
Publication statusPublished - 2015

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