TY - JOUR
T1 - One-pot multicomponent synthesis of bis(diamino-1,3,5-triazines) under microwave irradiation
AU - Bin Shahari, Muhammad Syafiq
AU - Tiekink, Edward R. T.
AU - Dolzhenko, Anton V.
N1 - Funding Information:
. This work is supported by the Ministry of Higher Education, Malaysia under Fundamental Research Grant Scheme (Grant no. FRGS/1/2020/STG04/MUSM/02/2). Sunway University Sdn Bhd is thanked for the financial support of the X‐ray crystallography laboratory (Grant no. GRTIN‐RRO‐56‐2022). Open Access publishing facilitated by Monash University, as part of the Wiley ‐ Monash University agreement via the Council of Australian University Librarians
Funding Information:
This work is supported by the Ministry of Higher Education, Malaysia under Fundamental Research Grant Scheme (Grant no. FRGS/1/2020/STG04/MUSM/02/2). Sunway University Sdn Bhd is thanked for the financial support of the X-ray crystallography laboratory (Grant no. GRTIN-RRO-56-2022). Open Access publishing facilitated by Monash University, as part of the Wiley - Monash University agreement via the Council of Australian University Librarians.
Publisher Copyright:
© 2022 The Authors. ChemistrySelect published by Wiley-VCH GmbH.
PY - 2022/11/25
Y1 - 2022/11/25
N2 - A new method for the synthesis of bis(1,3,5-triazine-2,4-diamines) was developed using a one-pot multicomponent approach. The synthesis was performed using the acid-catalyzed reaction of cyanoguanidine with amines and aldehydes, followed by dehydrogenative aromatization of the dihydrotriazine intermediates upon heating with alkali. Two types of bis(1,3,5-triazine-2,4-diamines) were prepared using either piperazine as the bifunctional amine or terephthaldehyde as the bifunctional aldehyde thus affording products with a piperazine or p-phenylene link between two 1,3,5-triazine rings. The microwave-assisted method allows fast and convenient synthesis of diverse bis(1,3,5-triazine-2,4-diamines).
AB - A new method for the synthesis of bis(1,3,5-triazine-2,4-diamines) was developed using a one-pot multicomponent approach. The synthesis was performed using the acid-catalyzed reaction of cyanoguanidine with amines and aldehydes, followed by dehydrogenative aromatization of the dihydrotriazine intermediates upon heating with alkali. Two types of bis(1,3,5-triazine-2,4-diamines) were prepared using either piperazine as the bifunctional amine or terephthaldehyde as the bifunctional aldehyde thus affording products with a piperazine or p-phenylene link between two 1,3,5-triazine rings. The microwave-assisted method allows fast and convenient synthesis of diverse bis(1,3,5-triazine-2,4-diamines).
KW - Dehydrogenative aromatization
KW - microwave chemistry
KW - microwave-assisted synthesis
KW - multicomponent reactions
KW - triazines
UR - http://www.scopus.com/inward/record.url?scp=85142606969&partnerID=8YFLogxK
U2 - 10.1002/slct.202203038
DO - 10.1002/slct.202203038
M3 - Article
AN - SCOPUS:85142606969
SN - 2365-6549
VL - 7
JO - ChemistrySelect
JF - ChemistrySelect
IS - 44
M1 - e202203038
ER -