On the trail of empty MHC class-I

Alexander Theodossis

doi:10.1016/j.molimm.2012.10.012

On the trail of empty MHC class-I

Alexander Theodossis

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

Since being proposed nearly 25years ago that MHC-I molecules free of peptide ligand possess a conformation that is distinct from that of the mature loaded form, considerable research has been conducted in order to isolate and characterise such a species. While some progress has been made in our understanding, many questions still surround the nature and loading of empty MHC-I. However, the necessary tools to address these questions may finally be at hand.

Original language	English
Pages (from-to)	131 - 134
Number of pages	4
Journal	Molecular Immunology
Volume	55
Issue number	2
DOIs	https://doi.org/10.1016/j.molimm.2012.10.012
Publication status	Published - 2013

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10.1016/j.molimm.2012.10.012

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abstract = "Since being proposed nearly 25years ago that MHC-I molecules free of peptide ligand possess a conformation that is distinct from that of the mature loaded form, considerable research has been conducted in order to isolate and characterise such a species. While some progress has been made in our understanding, many questions still surround the nature and loading of empty MHC-I. However, the necessary tools to address these questions may finally be at hand.",

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AB - Since being proposed nearly 25years ago that MHC-I molecules free of peptide ligand possess a conformation that is distinct from that of the mature loaded form, considerable research has been conducted in order to isolate and characterise such a species. While some progress has been made in our understanding, many questions still surround the nature and loading of empty MHC-I. However, the necessary tools to address these questions may finally be at hand.

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JO - Molecular Immunology

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On the trail of empty MHC class-I

Abstract

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