On the need of objective vigilance monitoring

Effects of sleep loss on target detection and task-negative activity using combined EEG/fMRI

Michael Czisch, Renate Wehrle, Helga A. Harsay, Thomas C. Wetter, Florian Holsboer, Philipp G. Sämann, Sean P A Drummond

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Sleep loss affects attention by reducing levels of arousal and alertness. The neural mechanisms underlying the compensatory efforts of the brain to maintain attention and performance after sleep deprivation (SD) are not fully understood. Previous neuroimaging studies of SD have not been able to separate the effects of reduced arousal from the effects of SD on cerebral responses to cognitive challenges. Here, we used a simultaneous electroen-cephalography (EEG) and functional magnetic resonance imaging (fMRI) approach to study the effects of 36 h of total sleep deprivation (TSD). Specifically, we focused on changes in selective attention processes as induced by an active acoustic oddball task, with the ability to isolate runs with objective EEG signs of high (SD alert) or reduced (SD Sleepy) vigilance. In the SD alert condition, oddball task-related activity appears to be sustained by compensatory co-activation of insular regions, but task-negative activity in the right posterior node of the default mode network is altered followingTSD. In the SD Sleepy condition, oddball task-positive activity was massively impaired, but task-negative activation was showing levels comparable with the control condition after a well-rested night. Our results suggest that loss of strict negative correlation between oddball task-positive and task-negative activation reflects the effects of TSD, while the actual state of vigilance during task performance can affects either task-related or task-negative activity, depending on the exact vigilance level.

Original languageEnglish
Article number67
Number of pages12
JournalFrontiers in Neurology
Volume3
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Arousal
  • Default mode
  • DMN
  • EEG
  • fMRI
  • Murtimodal imaging
  • Sleep deprivation
  • Vigilance

Cite this

Czisch, Michael ; Wehrle, Renate ; Harsay, Helga A. ; Wetter, Thomas C. ; Holsboer, Florian ; Sämann, Philipp G. ; Drummond, Sean P A. / On the need of objective vigilance monitoring : Effects of sleep loss on target detection and task-negative activity using combined EEG/fMRI. In: Frontiers in Neurology. 2012 ; Vol. 3.
@article{dfc5b674568c4ccea6fb689a9efaf380,
title = "On the need of objective vigilance monitoring: Effects of sleep loss on target detection and task-negative activity using combined EEG/fMRI",
abstract = "Sleep loss affects attention by reducing levels of arousal and alertness. The neural mechanisms underlying the compensatory efforts of the brain to maintain attention and performance after sleep deprivation (SD) are not fully understood. Previous neuroimaging studies of SD have not been able to separate the effects of reduced arousal from the effects of SD on cerebral responses to cognitive challenges. Here, we used a simultaneous electroen-cephalography (EEG) and functional magnetic resonance imaging (fMRI) approach to study the effects of 36 h of total sleep deprivation (TSD). Specifically, we focused on changes in selective attention processes as induced by an active acoustic oddball task, with the ability to isolate runs with objective EEG signs of high (SD alert) or reduced (SD Sleepy) vigilance. In the SD alert condition, oddball task-related activity appears to be sustained by compensatory co-activation of insular regions, but task-negative activity in the right posterior node of the default mode network is altered followingTSD. In the SD Sleepy condition, oddball task-positive activity was massively impaired, but task-negative activation was showing levels comparable with the control condition after a well-rested night. Our results suggest that loss of strict negative correlation between oddball task-positive and task-negative activation reflects the effects of TSD, while the actual state of vigilance during task performance can affects either task-related or task-negative activity, depending on the exact vigilance level.",
keywords = "Arousal, Default mode, DMN, EEG, fMRI, Murtimodal imaging, Sleep deprivation, Vigilance",
author = "Michael Czisch and Renate Wehrle and Harsay, {Helga A.} and Wetter, {Thomas C.} and Florian Holsboer and S{\"a}mann, {Philipp G.} and Drummond, {Sean P A}",
year = "2012",
doi = "10.3389/fneur.2012.00067",
language = "English",
volume = "3",
journal = "Frontiers in Neurology",
issn = "1664-2295",
publisher = "Frontiers Media",

}

On the need of objective vigilance monitoring : Effects of sleep loss on target detection and task-negative activity using combined EEG/fMRI. / Czisch, Michael; Wehrle, Renate; Harsay, Helga A.; Wetter, Thomas C.; Holsboer, Florian; Sämann, Philipp G.; Drummond, Sean P A.

In: Frontiers in Neurology, Vol. 3, 67, 2012.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - On the need of objective vigilance monitoring

T2 - Effects of sleep loss on target detection and task-negative activity using combined EEG/fMRI

AU - Czisch, Michael

AU - Wehrle, Renate

AU - Harsay, Helga A.

AU - Wetter, Thomas C.

AU - Holsboer, Florian

AU - Sämann, Philipp G.

AU - Drummond, Sean P A

PY - 2012

Y1 - 2012

N2 - Sleep loss affects attention by reducing levels of arousal and alertness. The neural mechanisms underlying the compensatory efforts of the brain to maintain attention and performance after sleep deprivation (SD) are not fully understood. Previous neuroimaging studies of SD have not been able to separate the effects of reduced arousal from the effects of SD on cerebral responses to cognitive challenges. Here, we used a simultaneous electroen-cephalography (EEG) and functional magnetic resonance imaging (fMRI) approach to study the effects of 36 h of total sleep deprivation (TSD). Specifically, we focused on changes in selective attention processes as induced by an active acoustic oddball task, with the ability to isolate runs with objective EEG signs of high (SD alert) or reduced (SD Sleepy) vigilance. In the SD alert condition, oddball task-related activity appears to be sustained by compensatory co-activation of insular regions, but task-negative activity in the right posterior node of the default mode network is altered followingTSD. In the SD Sleepy condition, oddball task-positive activity was massively impaired, but task-negative activation was showing levels comparable with the control condition after a well-rested night. Our results suggest that loss of strict negative correlation between oddball task-positive and task-negative activation reflects the effects of TSD, while the actual state of vigilance during task performance can affects either task-related or task-negative activity, depending on the exact vigilance level.

AB - Sleep loss affects attention by reducing levels of arousal and alertness. The neural mechanisms underlying the compensatory efforts of the brain to maintain attention and performance after sleep deprivation (SD) are not fully understood. Previous neuroimaging studies of SD have not been able to separate the effects of reduced arousal from the effects of SD on cerebral responses to cognitive challenges. Here, we used a simultaneous electroen-cephalography (EEG) and functional magnetic resonance imaging (fMRI) approach to study the effects of 36 h of total sleep deprivation (TSD). Specifically, we focused on changes in selective attention processes as induced by an active acoustic oddball task, with the ability to isolate runs with objective EEG signs of high (SD alert) or reduced (SD Sleepy) vigilance. In the SD alert condition, oddball task-related activity appears to be sustained by compensatory co-activation of insular regions, but task-negative activity in the right posterior node of the default mode network is altered followingTSD. In the SD Sleepy condition, oddball task-positive activity was massively impaired, but task-negative activation was showing levels comparable with the control condition after a well-rested night. Our results suggest that loss of strict negative correlation between oddball task-positive and task-negative activation reflects the effects of TSD, while the actual state of vigilance during task performance can affects either task-related or task-negative activity, depending on the exact vigilance level.

KW - Arousal

KW - Default mode

KW - DMN

KW - EEG

KW - fMRI

KW - Murtimodal imaging

KW - Sleep deprivation

KW - Vigilance

UR - http://www.scopus.com/inward/record.url?scp=84865972725&partnerID=8YFLogxK

U2 - 10.3389/fneur.2012.00067

DO - 10.3389/fneur.2012.00067

M3 - Article

VL - 3

JO - Frontiers in Neurology

JF - Frontiers in Neurology

SN - 1664-2295

M1 - 67

ER -