On spray drying of oxidized corn starch cross-linked gelatin microcapsules for drug release

Xugang Dang, Mao Yang, Zhihua Shan, Shahnaz Mansouri, Bee K May, Xiaodong Chen, Hui Chen, Meng Wai Woo

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Abstract

Spray-dried gelatin/oxidized corn starch (G/OCS) microcapsules were produced for drug release application. The prepared microcapsules were characterized through a scanning electron microscope (SEM) picture and thermogravimetric analysis (TGA). The swelling characteristics of the G/OCS microcapsules and release properties of vitamin C were then investigated. The results from structural analysis indicated that the presence of miscibility and compatibility between oxidized corn starch and gelatin, and exhibits high thermal stability up to 326. C. The swelling of G/OCS microcapsules increased with increasing pH and reduced with decreasing ionic strength, attributed to the cross-linking between gelatin and oxidized corn starch, ionization of functional groups. Vitamin C release characteristic revealed controlled release behavior in the first 3. h of contact with an aqueous medium. This release behavior was independent of the swelling behavior indicating the potential of the encapsulating matrix to produce controlled release across a spectrum of pH environment.

Original languageEnglish
Pages (from-to)493-500
Number of pages8
JournalMaterials Science and Engineering C: Materials for Biological Applications
Volume74
DOIs
Publication statusPublished - 1 May 2017

Keywords

  • Gelatin
  • Microcapsules
  • Oxidized corn starch

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