Oliguria as predictive biomarker of acute kidney injury in critically ill patients

John Prowle; Yan-Lun Liu; Elisa Licari; Sean Bagshaw; Moritoki Egi; Michael Haase; Anja Haase-Fielitz; John Kellum; Dinna Cruz; Claudio Ronco; Kenji Tsutsui; Shigehiko Uchino; Rinaldo Bellomo

doi:10.1186/cc10318

Oliguria as predictive biomarker of acute kidney injury in critically ill patients

John Prowle, Yan-Lun Liu, Elisa Licari, Sean Bagshaw, Moritoki Egi, Michael Haase, Anja Haase-Fielitz, John Kellum, Dinna Cruz, Claudio Ronco, Kenji Tsutsui, Shigehiko Uchino, Rinaldo Bellomo

School of Public Health and Preventive Medicine

Research output: Contribution to journal › Article › Research › peer-review

188 Citations (Scopus)

Abstract

During critical illness, oliguria is often used as a biomarker of acute kidney injury (AKI). However, its relationship with the subsequent development of AKI has not been prospectively evaluated.Methods: We documented urine output and daily serum creatinine concentration in patients admitted for more than 24 hours in seven intensive care units (ICUs) from six countries over a period of two to four weeks. Oliguria was defined by a urine output <0.5 ml/kg/hr. Data were collected until the occurrence of creatinine-defined AKI (AKI-Cr), designated by RIFLE-Injury class or greater using creatinine criteria (RIFLE-I[Cr]), or until ICU discharge. Episodes of oliguria were classified by longest duration of consecutive oliguria during each day were correlated with new AKI-Cr the next day, examining cut-offs for oliguria of greater than 1,2,3,4,5,6, or 12 hr duration,. Results: We studied 239 patients during 723 days.

Original language	English
Article number	R172
Number of pages	10
Journal	Critical Care
Volume	15
Issue number	4
DOIs	https://doi.org/10.1186/cc10318
Publication status	Published - 2011

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10.1186/cc10318

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title = "Oliguria as predictive biomarker of acute kidney injury in critically ill patients",

abstract = "During critical illness, oliguria is often used as a biomarker of acute kidney injury (AKI). However, its relationship with the subsequent development of AKI has not been prospectively evaluated.Methods: We documented urine output and daily serum creatinine concentration in patients admitted for more than 24 hours in seven intensive care units (ICUs) from six countries over a period of two to four weeks. Oliguria was defined by a urine output <0.5 ml/kg/hr. Data were collected until the occurrence of creatinine-defined AKI (AKI-Cr), designated by RIFLE-Injury class or greater using creatinine criteria (RIFLE-I[Cr]), or until ICU discharge. Episodes of oliguria were classified by longest duration of consecutive oliguria during each day were correlated with new AKI-Cr the next day, examining cut-offs for oliguria of greater than 1,2,3,4,5,6, or 12 hr duration,. Results: We studied 239 patients during 723 days.",

author = "John Prowle and Yan-Lun Liu and Elisa Licari and Sean Bagshaw and Moritoki Egi and Michael Haase and Anja Haase-Fielitz and John Kellum and Dinna Cruz and Claudio Ronco and Kenji Tsutsui and Shigehiko Uchino and Rinaldo Bellomo",

year = "2011",

doi = "10.1186/cc10318",

language = "English",

volume = "15",

journal = "Critical Care",

issn = "1364-8535",

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TY - JOUR

T1 - Oliguria as predictive biomarker of acute kidney injury in critically ill patients

AU - Prowle, John

AU - Liu, Yan-Lun

AU - Licari, Elisa

AU - Bagshaw, Sean

AU - Egi, Moritoki

AU - Haase, Michael

AU - Haase-Fielitz, Anja

AU - Kellum, John

AU - Cruz, Dinna

AU - Ronco, Claudio

AU - Tsutsui, Kenji

AU - Uchino, Shigehiko

AU - Bellomo, Rinaldo

PY - 2011

Y1 - 2011

N2 - During critical illness, oliguria is often used as a biomarker of acute kidney injury (AKI). However, its relationship with the subsequent development of AKI has not been prospectively evaluated.Methods: We documented urine output and daily serum creatinine concentration in patients admitted for more than 24 hours in seven intensive care units (ICUs) from six countries over a period of two to four weeks. Oliguria was defined by a urine output <0.5 ml/kg/hr. Data were collected until the occurrence of creatinine-defined AKI (AKI-Cr), designated by RIFLE-Injury class or greater using creatinine criteria (RIFLE-I[Cr]), or until ICU discharge. Episodes of oliguria were classified by longest duration of consecutive oliguria during each day were correlated with new AKI-Cr the next day, examining cut-offs for oliguria of greater than 1,2,3,4,5,6, or 12 hr duration,. Results: We studied 239 patients during 723 days.

AB - During critical illness, oliguria is often used as a biomarker of acute kidney injury (AKI). However, its relationship with the subsequent development of AKI has not been prospectively evaluated.Methods: We documented urine output and daily serum creatinine concentration in patients admitted for more than 24 hours in seven intensive care units (ICUs) from six countries over a period of two to four weeks. Oliguria was defined by a urine output <0.5 ml/kg/hr. Data were collected until the occurrence of creatinine-defined AKI (AKI-Cr), designated by RIFLE-Injury class or greater using creatinine criteria (RIFLE-I[Cr]), or until ICU discharge. Episodes of oliguria were classified by longest duration of consecutive oliguria during each day were correlated with new AKI-Cr the next day, examining cut-offs for oliguria of greater than 1,2,3,4,5,6, or 12 hr duration,. Results: We studied 239 patients during 723 days.

U2 - 10.1186/cc10318

DO - 10.1186/cc10318

M3 - Article

SN - 1364-8535

VL - 15

JO - Critical Care

JF - Critical Care

IS - 4

M1 - R172

ER -