Oligonephronia: another piece in the CKDu jigsaw?

Wendy E. Hoy, John F. Bertram

Research output: Contribution to journalComment / DebateOtherpeer-review


Rates of chronic kidney disease of unknown etiology are high in Aguascalientes, Mexico. Kidneys of adolescents are small by ultrasonography, compatible with oligonephronia, whereas proteinuria and higher estimated glomerular filtration rates and blood pressures among those with relatively higher kidney volumes probably flag relatively greater degrees of compensatory hypertrophy. Glomerulomegaly and podocytopathy, and later segmental glomerulosclerosis in biopsies, suggest a cascade driven by nephron deficiency. Better measures of glomerular number and volume should improve understanding, facilitate risk assessment, and guide interventions.

Original languageEnglish
Pages (from-to)671-673
Number of pages3
JournalKidney International
Issue number4
Publication statusPublished - Apr 2024

Cite this