Oligodendrocytes: Cells of origin for white matter injury in the developing brain

Mary Tolcos, David H Rowitch, Justin Dean

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)


A prominent pattern of brain injury in preterm born infants involves damage to white matter with impaired oligodendrocyte maturation. This results in diffuse deficits in myelination that are associated with later development of cerebral palsy. While numerous experimental animal models of perinatal white matter injury have been developed, they show a spectrum of effects. This review proposes that adopting a more standard approach to defining white matter injury is important for validating experimental findings against the bona fide human condition. This chapter will describe the pathology of perinatal white matter injury and a general methodological approach for assessing white matter injury experimentally.
Original languageEnglish
Title of host publicationPrenatal and Postnatal Determinants of Development
EditorsDavid W Walker
Place of PublicationNew York NY USA
PublisherHumana Press
Number of pages21
ISBN (Print)9781493930135
Publication statusPublished - 2015
Externally publishedYes

Publication series

NameNeuromethods: Springer protocols
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

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