Oestradiol supplement minimises coronary occlusion-induced myocardial infarction and ventricular dysfunction in oophorectomised female rats

Xiao-Pu Zheng, Ai-Qun Ma, Shun Wang, Wen-Hui Jiang, Ting-Zhong Wang, Fen-Ling Fan, Shanhong Ling

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6 Citations (Scopus)

Abstract

BACKGROUND: Endogenous oestrogen deficiency after menopause is associated with high risk of acute cardiac events and the protection of exogenous oestrogen supplements remains uncertain. This study investigates whether oestrogen therapy protects the heart from ischemic injury in oophorectomised rats. METHODS: Sexually mature female Sprague-Dawley rats (6 for each group) with bilateral oophorectomy underwent selective ligation (occlusion) of left coronary artery for 4weeks. 17beta-oestradiol (E2) supplements (10mug, i.m., every other day) were started before (preventive-therapeutic supplement) or after coronary occlusion (therapeutic supplement). RESULTS: In oophorectomised rats plasma levels of E2 declined from 1301+/-80 to 196+/-48pmol/L (p
Original languageEnglish
Pages (from-to)290 - 295
Number of pages5
JournalInternational Journal of Cardiology
Volume151
DOIs
Publication statusPublished - 2011

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