TY - JOUR
T1 - Oculomotor deficits in attention deficit hyperactivity disorder (ADHD)
T2 - A systematic review and comprehensive meta-analysis
AU - Maron, Dalia N.
AU - Bowe, Steven J.
AU - Spencer-Smith, Megan
AU - Mellahn, Olivia J.
AU - Perrykkad, Kelsey
AU - Bellgrove, Mark A.
AU - Johnson, Beth P.
N1 - Funding Information:
This work is funded by a grant to M.A.B and B.P.J by the Australian Medical Research Future Fund/Department of Health ( EPCD000002 ). Kelsey Perrykkad is supported by an Australian Government Research Training Program (RTP) Scholarship . Mark A. Bellgrove is additionally funded by a Senior Research Fellowship (Level B) from the National Health and Medical Research Council (NHMRC) of Australia. Beth P. Johnson is funded by an NHMRC Peter Doherty Early Career Fellowship ( APP1112348 NHMRC ).
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/12
Y1 - 2021/12
N2 - Atypical motor coordination and cognitive processes, such as response inhibition and working memory, have been extensively researched in individuals with attention deficit hyperactivity disorder (ADHD). Oculomotor neural circuits overlap extensively with regions involved in motor planning and cognition, therefore studies of oculomotor function may offer unique insights into motor and cognitive control in ADHD. We performed a series of pairwise meta-analyses based on data from 26 oculomotor studies in ADHD to examine whether there were differences in performance on visually-guided saccade, gap, antisaccade, memory-guided, pursuit eye movements and fixation tasks. These analyses revealed oculomotor disturbances in ADHD, particularly for difficulties relating to saccade inhibition, memorizing visual target locations and initiating antisaccades. There was no evidence for pursuit eye movement disturbances or saccade dysmetria. Investigating oculomotor abnormalities in ADHD may provide insight into top-down cognitive control processes and motor control, and may serve as a promising biomarker in ADHD research and clinical practice.
AB - Atypical motor coordination and cognitive processes, such as response inhibition and working memory, have been extensively researched in individuals with attention deficit hyperactivity disorder (ADHD). Oculomotor neural circuits overlap extensively with regions involved in motor planning and cognition, therefore studies of oculomotor function may offer unique insights into motor and cognitive control in ADHD. We performed a series of pairwise meta-analyses based on data from 26 oculomotor studies in ADHD to examine whether there were differences in performance on visually-guided saccade, gap, antisaccade, memory-guided, pursuit eye movements and fixation tasks. These analyses revealed oculomotor disturbances in ADHD, particularly for difficulties relating to saccade inhibition, memorizing visual target locations and initiating antisaccades. There was no evidence for pursuit eye movement disturbances or saccade dysmetria. Investigating oculomotor abnormalities in ADHD may provide insight into top-down cognitive control processes and motor control, and may serve as a promising biomarker in ADHD research and clinical practice.
KW - ADHD
KW - Inhibition
KW - Motor coordination
KW - Oculomotor
KW - Working memory
UR - http://www.scopus.com/inward/record.url?scp=85118478218&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2021.10.012
DO - 10.1016/j.neubiorev.2021.10.012
M3 - Review Article
AN - SCOPUS:85118478218
VL - 131
SP - 1198
EP - 1213
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
ER -