Oculomotor deficits in attention deficit hyperactivity disorder (ADHD): A systematic review and comprehensive meta-analysis

Dalia N. Maron, Steven J. Bowe, Megan Spencer-Smith, Olivia J. Mellahn, Kelsey Perrykkad, Mark A. Bellgrove, Beth P. Johnson

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Atypical motor coordination and cognitive processes, such as response inhibition and working memory, have been extensively researched in individuals with attention deficit hyperactivity disorder (ADHD). Oculomotor neural circuits overlap extensively with regions involved in motor planning and cognition, therefore studies of oculomotor function may offer unique insights into motor and cognitive control in ADHD. We performed a series of pairwise meta-analyses based on data from 26 oculomotor studies in ADHD to examine whether there were differences in performance on visually-guided saccade, gap, antisaccade, memory-guided, pursuit eye movements and fixation tasks. These analyses revealed oculomotor disturbances in ADHD, particularly for difficulties relating to saccade inhibition, memorizing visual target locations and initiating antisaccades. There was no evidence for pursuit eye movement disturbances or saccade dysmetria. Investigating oculomotor abnormalities in ADHD may provide insight into top-down cognitive control processes and motor control, and may serve as a promising biomarker in ADHD research and clinical practice.

Original languageEnglish
Pages (from-to)1198-1213
Number of pages16
JournalNeuroscience and Biobehavioral Reviews
Volume131
DOIs
Publication statusPublished - Dec 2021

Keywords

  • ADHD
  • Inhibition
  • Motor coordination
  • Oculomotor
  • Working memory

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