Occupational exposures to solvents and metals are associated with fixed airflow obstruction

Sheikh M. Alif, Shyamali C. Dharmage, Geza Benke, Martine Dennekamp, John A. Burgess, Jennifer L. Perret, Caroline J. Lodge, Stephen Morrison, David P. Johns, Graham G. Giles, Lyle C. Gurrin, Paul S. Thomas, John L. Hopper, Richard Wood-Baker, Bruce R. Thompson, Iain H. Feather, Roel Vermeulen, Hans Kromhout, E. Haydn Walters, Michael J. Abramson & 1 others Melanie C. Matheson

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objectives This study investigated the associations between occupational exposures to solvents and metals and fixed airflow obstruction (AO) using post-bronchodilator spirometry. Methods We included 1335 participants from the 2002–2008 follow-up of the Tasmanian Longitudinal Health Study. Ever-exposure and cumulative exposure-unit (EU) years were calculated using the ALOHA plus job exposure matrix (JEM). Fixed AO was defined as post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) <0.7 and FEV1/FVC<lower limit of normal. Diffusing capacity of the lung for carbon monoxide (DLCO) was combined with FEV1/FVC<0.7 to define fixed AO plus low DLCO. Multinomial regressions were used to estimate associations adjusting for possible confounders. Results Ever-exposure to metals was associated with fixed AO [relative risk (RR) 1.71, 95% CI 1.03–2.85] and fixed AO lower limit of normal (RR 1.67, 95% CI 1.00–2.78). Women had lower cumulative EU years to chlorinated solvents [mean 20.9, standard deviation (SD) 13.4] than men (mean 28.6, SD 36.9). However, the risk of developing fixed AO and fixed AO plus low DLCO associated with each cumulative EU year of chlorinated solvents were higher among women than men (RR 1.08 versus 0.99, P-value for effect measure modification=0.006; RR 1.08 versus 1.00, P-value for effect measure modification=0.02). Conclusions We have shown ever-exposure to metals and chlorinated solvents are important risk factors for fixed AO. The effects for solvents were strongest among women. Preventive strategies need to be followed to reduce these exposures at the workplace.

Original languageEnglish
Pages (from-to)595-603
Number of pages9
JournalScandinavian Journal of Work, Environment and Health
Volume43
Issue number6
DOIs
Publication statusPublished - 2017

Keywords

  • ALOHA
  • Chlorinated solvent
  • Chronic obstructive pulmonary disease
  • COPD
  • JEM
  • Job exposure matrix

Cite this

Alif, Sheikh M. ; Dharmage, Shyamali C. ; Benke, Geza ; Dennekamp, Martine ; Burgess, John A. ; Perret, Jennifer L. ; Lodge, Caroline J. ; Morrison, Stephen ; Johns, David P. ; Giles, Graham G. ; Gurrin, Lyle C. ; Thomas, Paul S. ; Hopper, John L. ; Wood-Baker, Richard ; Thompson, Bruce R. ; Feather, Iain H. ; Vermeulen, Roel ; Kromhout, Hans ; Haydn Walters, E. ; Abramson, Michael J. ; Matheson, Melanie C. / Occupational exposures to solvents and metals are associated with fixed airflow obstruction. In: Scandinavian Journal of Work, Environment and Health. 2017 ; Vol. 43, No. 6. pp. 595-603.
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abstract = "Objectives This study investigated the associations between occupational exposures to solvents and metals and fixed airflow obstruction (AO) using post-bronchodilator spirometry. Methods We included 1335 participants from the 2002–2008 follow-up of the Tasmanian Longitudinal Health Study. Ever-exposure and cumulative exposure-unit (EU) years were calculated using the ALOHA plus job exposure matrix (JEM). Fixed AO was defined as post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) <0.7 and FEV1/FVC",
keywords = "ALOHA, Chlorinated solvent, Chronic obstructive pulmonary disease, COPD, JEM, Job exposure matrix",
author = "Alif, {Sheikh M.} and Dharmage, {Shyamali C.} and Geza Benke and Martine Dennekamp and Burgess, {John A.} and Perret, {Jennifer L.} and Lodge, {Caroline J.} and Stephen Morrison and Johns, {David P.} and Giles, {Graham G.} and Gurrin, {Lyle C.} and Thomas, {Paul S.} and Hopper, {John L.} and Richard Wood-Baker and Thompson, {Bruce R.} and Feather, {Iain H.} and Roel Vermeulen and Hans Kromhout and {Haydn Walters}, E. and Abramson, {Michael J.} and Matheson, {Melanie C.}",
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Alif, SM, Dharmage, SC, Benke, G, Dennekamp, M, Burgess, JA, Perret, JL, Lodge, CJ, Morrison, S, Johns, DP, Giles, GG, Gurrin, LC, Thomas, PS, Hopper, JL, Wood-Baker, R, Thompson, BR, Feather, IH, Vermeulen, R, Kromhout, H, Haydn Walters, E, Abramson, MJ & Matheson, MC 2017, 'Occupational exposures to solvents and metals are associated with fixed airflow obstruction' Scandinavian Journal of Work, Environment and Health, vol. 43, no. 6, pp. 595-603. https://doi.org/10.5271/sjweh.3662

Occupational exposures to solvents and metals are associated with fixed airflow obstruction. / Alif, Sheikh M.; Dharmage, Shyamali C.; Benke, Geza; Dennekamp, Martine; Burgess, John A.; Perret, Jennifer L.; Lodge, Caroline J.; Morrison, Stephen; Johns, David P.; Giles, Graham G.; Gurrin, Lyle C.; Thomas, Paul S.; Hopper, John L.; Wood-Baker, Richard; Thompson, Bruce R.; Feather, Iain H.; Vermeulen, Roel; Kromhout, Hans; Haydn Walters, E.; Abramson, Michael J.; Matheson, Melanie C.

In: Scandinavian Journal of Work, Environment and Health, Vol. 43, No. 6, 2017, p. 595-603.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Occupational exposures to solvents and metals are associated with fixed airflow obstruction

AU - Alif, Sheikh M.

AU - Dharmage, Shyamali C.

AU - Benke, Geza

AU - Dennekamp, Martine

AU - Burgess, John A.

AU - Perret, Jennifer L.

AU - Lodge, Caroline J.

AU - Morrison, Stephen

AU - Johns, David P.

AU - Giles, Graham G.

AU - Gurrin, Lyle C.

AU - Thomas, Paul S.

AU - Hopper, John L.

AU - Wood-Baker, Richard

AU - Thompson, Bruce R.

AU - Feather, Iain H.

AU - Vermeulen, Roel

AU - Kromhout, Hans

AU - Haydn Walters, E.

AU - Abramson, Michael J.

AU - Matheson, Melanie C.

PY - 2017

Y1 - 2017

N2 - Objectives This study investigated the associations between occupational exposures to solvents and metals and fixed airflow obstruction (AO) using post-bronchodilator spirometry. Methods We included 1335 participants from the 2002–2008 follow-up of the Tasmanian Longitudinal Health Study. Ever-exposure and cumulative exposure-unit (EU) years were calculated using the ALOHA plus job exposure matrix (JEM). Fixed AO was defined as post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) <0.7 and FEV1/FVC

AB - Objectives This study investigated the associations between occupational exposures to solvents and metals and fixed airflow obstruction (AO) using post-bronchodilator spirometry. Methods We included 1335 participants from the 2002–2008 follow-up of the Tasmanian Longitudinal Health Study. Ever-exposure and cumulative exposure-unit (EU) years were calculated using the ALOHA plus job exposure matrix (JEM). Fixed AO was defined as post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) <0.7 and FEV1/FVC

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KW - Chlorinated solvent

KW - Chronic obstructive pulmonary disease

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M3 - Article

VL - 43

SP - 595

EP - 603

JO - Scandinavian Journal of Work, Environment and Health

JF - Scandinavian Journal of Work, Environment and Health

SN - 0355-3140

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ER -