Occupational exposure to solvents and lung function decline

Alif

Sheikh M. Alif, Shyamali Dharmage, Geza Benke, Martine Dennekamp, John Burgess, Jennifer L. Perret, Caroline Lodge, Stephen Morrison, David Peter Johns, Graham Giles, Lyle Gurrin, Paul S. Thomas, John Llewelyn Hopper, Richard Wood-Baker, Bruce Thompson, Iain Feather, Roel Vermeulen, Hans Kromhout, Debbie Jarvis, Judith Garcia Aymerich & 3 others E. Haydn Walters, Michael J. Abramson, Melanie Claire Matheson

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Rationale: While cross-sectional studies have shown associations between certain occupational exposures and lower levels of lung function, there was little evidence from population-based studies with repeated lung function measurements. Objectives: We aimed to investigate the associations between occupational exposures and longitudinal lung function decline in the population-based Tasmanian Longitudinal Health Study. Methods: Lung function decline between ages 45 years and 50 years was assessed using data from 767 participants. Using lifetime work history calendars completed at age 45 years, exposures were assigned according to the ALOHA plus Job Exposure Matrix. Occupational exposures were defined as ever exposed and cumulative exposure -unit- years. We investigated effect modification by sex, smoking and asthma status. Results: Compared with those without exposure, ever exposures to aromatic solvents and metals were associated with a greater decline in FEV 1 (aromatic solvents 15.5 mL/year (95% CI '24.8 to 6.3); metals 11.3 mL/year (95% CI '21.9 to - 0.7)) and FVC (aromatic solvents 14.1 mL/year 95% CI '28.8 to - 0.7; metals 17.5 mL/year (95% CI -34.3 to - 0.8)). Cumulative exposure (unit years) to aromatic solvents was also associated with greater decline in FEV 1 and FVC. Women had lower cumulative exposure years to aromatic solvents than men (mean (SD) 9.6 (15.5) vs 16.6 (14.6)), but greater lung function decline than men. We also found association between ever exposures to gases/fumes or mineral dust and greater decline in lung function. Conclusions: Exposures to aromatic solvents and metals were associated with greater lung function decline. The effect of aromatic solvents was strongest in women. Preventive strategies should be implemented to reduce these exposures in the workplace.

Original languageEnglish
Pages (from-to)650-658
Number of pages9
JournalThorax
Volume74
Issue number7
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • chronic obstructive pulmonary disease
  • FEV1
  • job exposure matrix
  • lung function
  • occupational exposure
  • solvents

Cite this

Alif, Sheikh M. ; Dharmage, Shyamali ; Benke, Geza ; Dennekamp, Martine ; Burgess, John ; Perret, Jennifer L. ; Lodge, Caroline ; Morrison, Stephen ; Johns, David Peter ; Giles, Graham ; Gurrin, Lyle ; Thomas, Paul S. ; Hopper, John Llewelyn ; Wood-Baker, Richard ; Thompson, Bruce ; Feather, Iain ; Vermeulen, Roel ; Kromhout, Hans ; Jarvis, Debbie ; Garcia Aymerich, Judith ; Walters, E. Haydn ; Abramson, Michael J. ; Matheson, Melanie Claire. / Occupational exposure to solvents and lung function decline : Alif. In: Thorax. 2019 ; Vol. 74, No. 7. pp. 650-658.
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title = "Occupational exposure to solvents and lung function decline: Alif",
abstract = "Rationale: While cross-sectional studies have shown associations between certain occupational exposures and lower levels of lung function, there was little evidence from population-based studies with repeated lung function measurements. Objectives: We aimed to investigate the associations between occupational exposures and longitudinal lung function decline in the population-based Tasmanian Longitudinal Health Study. Methods: Lung function decline between ages 45 years and 50 years was assessed using data from 767 participants. Using lifetime work history calendars completed at age 45 years, exposures were assigned according to the ALOHA plus Job Exposure Matrix. Occupational exposures were defined as ever exposed and cumulative exposure -unit- years. We investigated effect modification by sex, smoking and asthma status. Results: Compared with those without exposure, ever exposures to aromatic solvents and metals were associated with a greater decline in FEV 1 (aromatic solvents 15.5 mL/year (95{\%} CI '24.8 to 6.3); metals 11.3 mL/year (95{\%} CI '21.9 to - 0.7)) and FVC (aromatic solvents 14.1 mL/year 95{\%} CI '28.8 to - 0.7; metals 17.5 mL/year (95{\%} CI -34.3 to - 0.8)). Cumulative exposure (unit years) to aromatic solvents was also associated with greater decline in FEV 1 and FVC. Women had lower cumulative exposure years to aromatic solvents than men (mean (SD) 9.6 (15.5) vs 16.6 (14.6)), but greater lung function decline than men. We also found association between ever exposures to gases/fumes or mineral dust and greater decline in lung function. Conclusions: Exposures to aromatic solvents and metals were associated with greater lung function decline. The effect of aromatic solvents was strongest in women. Preventive strategies should be implemented to reduce these exposures in the workplace.",
keywords = "chronic obstructive pulmonary disease, FEV1, job exposure matrix, lung function, occupational exposure, solvents",
author = "Alif, {Sheikh M.} and Shyamali Dharmage and Geza Benke and Martine Dennekamp and John Burgess and Perret, {Jennifer L.} and Caroline Lodge and Stephen Morrison and Johns, {David Peter} and Graham Giles and Lyle Gurrin and Thomas, {Paul S.} and Hopper, {John Llewelyn} and Richard Wood-Baker and Bruce Thompson and Iain Feather and Roel Vermeulen and Hans Kromhout and Debbie Jarvis and {Garcia Aymerich}, Judith and Walters, {E. Haydn} and Abramson, {Michael J.} and Matheson, {Melanie Claire}",
year = "2019",
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doi = "10.1136/thoraxjnl-2018-212267",
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Alif, SM, Dharmage, S, Benke, G, Dennekamp, M, Burgess, J, Perret, JL, Lodge, C, Morrison, S, Johns, DP, Giles, G, Gurrin, L, Thomas, PS, Hopper, JL, Wood-Baker, R, Thompson, B, Feather, I, Vermeulen, R, Kromhout, H, Jarvis, D, Garcia Aymerich, J, Walters, EH, Abramson, MJ & Matheson, MC 2019, 'Occupational exposure to solvents and lung function decline: Alif', Thorax, vol. 74, no. 7, pp. 650-658. https://doi.org/10.1136/thoraxjnl-2018-212267

Occupational exposure to solvents and lung function decline : Alif. / Alif, Sheikh M.; Dharmage, Shyamali; Benke, Geza; Dennekamp, Martine; Burgess, John; Perret, Jennifer L.; Lodge, Caroline; Morrison, Stephen; Johns, David Peter; Giles, Graham; Gurrin, Lyle; Thomas, Paul S.; Hopper, John Llewelyn; Wood-Baker, Richard; Thompson, Bruce; Feather, Iain; Vermeulen, Roel; Kromhout, Hans; Jarvis, Debbie; Garcia Aymerich, Judith; Walters, E. Haydn; Abramson, Michael J.; Matheson, Melanie Claire.

In: Thorax, Vol. 74, No. 7, 01.01.2019, p. 650-658.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Occupational exposure to solvents and lung function decline

T2 - Alif

AU - Alif, Sheikh M.

AU - Dharmage, Shyamali

AU - Benke, Geza

AU - Dennekamp, Martine

AU - Burgess, John

AU - Perret, Jennifer L.

AU - Lodge, Caroline

AU - Morrison, Stephen

AU - Johns, David Peter

AU - Giles, Graham

AU - Gurrin, Lyle

AU - Thomas, Paul S.

AU - Hopper, John Llewelyn

AU - Wood-Baker, Richard

AU - Thompson, Bruce

AU - Feather, Iain

AU - Vermeulen, Roel

AU - Kromhout, Hans

AU - Jarvis, Debbie

AU - Garcia Aymerich, Judith

AU - Walters, E. Haydn

AU - Abramson, Michael J.

AU - Matheson, Melanie Claire

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Rationale: While cross-sectional studies have shown associations between certain occupational exposures and lower levels of lung function, there was little evidence from population-based studies with repeated lung function measurements. Objectives: We aimed to investigate the associations between occupational exposures and longitudinal lung function decline in the population-based Tasmanian Longitudinal Health Study. Methods: Lung function decline between ages 45 years and 50 years was assessed using data from 767 participants. Using lifetime work history calendars completed at age 45 years, exposures were assigned according to the ALOHA plus Job Exposure Matrix. Occupational exposures were defined as ever exposed and cumulative exposure -unit- years. We investigated effect modification by sex, smoking and asthma status. Results: Compared with those without exposure, ever exposures to aromatic solvents and metals were associated with a greater decline in FEV 1 (aromatic solvents 15.5 mL/year (95% CI '24.8 to 6.3); metals 11.3 mL/year (95% CI '21.9 to - 0.7)) and FVC (aromatic solvents 14.1 mL/year 95% CI '28.8 to - 0.7; metals 17.5 mL/year (95% CI -34.3 to - 0.8)). Cumulative exposure (unit years) to aromatic solvents was also associated with greater decline in FEV 1 and FVC. Women had lower cumulative exposure years to aromatic solvents than men (mean (SD) 9.6 (15.5) vs 16.6 (14.6)), but greater lung function decline than men. We also found association between ever exposures to gases/fumes or mineral dust and greater decline in lung function. Conclusions: Exposures to aromatic solvents and metals were associated with greater lung function decline. The effect of aromatic solvents was strongest in women. Preventive strategies should be implemented to reduce these exposures in the workplace.

AB - Rationale: While cross-sectional studies have shown associations between certain occupational exposures and lower levels of lung function, there was little evidence from population-based studies with repeated lung function measurements. Objectives: We aimed to investigate the associations between occupational exposures and longitudinal lung function decline in the population-based Tasmanian Longitudinal Health Study. Methods: Lung function decline between ages 45 years and 50 years was assessed using data from 767 participants. Using lifetime work history calendars completed at age 45 years, exposures were assigned according to the ALOHA plus Job Exposure Matrix. Occupational exposures were defined as ever exposed and cumulative exposure -unit- years. We investigated effect modification by sex, smoking and asthma status. Results: Compared with those without exposure, ever exposures to aromatic solvents and metals were associated with a greater decline in FEV 1 (aromatic solvents 15.5 mL/year (95% CI '24.8 to 6.3); metals 11.3 mL/year (95% CI '21.9 to - 0.7)) and FVC (aromatic solvents 14.1 mL/year 95% CI '28.8 to - 0.7; metals 17.5 mL/year (95% CI -34.3 to - 0.8)). Cumulative exposure (unit years) to aromatic solvents was also associated with greater decline in FEV 1 and FVC. Women had lower cumulative exposure years to aromatic solvents than men (mean (SD) 9.6 (15.5) vs 16.6 (14.6)), but greater lung function decline than men. We also found association between ever exposures to gases/fumes or mineral dust and greater decline in lung function. Conclusions: Exposures to aromatic solvents and metals were associated with greater lung function decline. The effect of aromatic solvents was strongest in women. Preventive strategies should be implemented to reduce these exposures in the workplace.

KW - chronic obstructive pulmonary disease

KW - FEV1

KW - job exposure matrix

KW - lung function

KW - occupational exposure

KW - solvents

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U2 - 10.1136/thoraxjnl-2018-212267

DO - 10.1136/thoraxjnl-2018-212267

M3 - Article

VL - 74

SP - 650

EP - 658

JO - Thorax

JF - Thorax

SN - 0040-6376

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