Objective assessment of endoscopic disease activity and mucosal healing

Britt Christensen, David T. Rubin

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

In patients with inflammatory bowel disease, mucosal healing is associated with improved clinical outcomes including prolonged remission, decreased hospitalizations and surgery, and decreased colorectal cancer risk. Objective assessment of endoscopic disease activity and treating to achieve mucosal healing is increasingly being incorporated as an endpoint in clinical trials and as part of standard clinical care. However currently there is no consensus on the definition of mucosal improvement and healing and there are limited validated endoscopic scoring systems available. This chapter discusses the role of endoscopy and mucosal disease activity in prognosticating the disease course and the benefits of achieving mucosal healing in IBD. In addition, we critically analyze the currently available endoscopic scoring systems from the point of view of clinical trials and clinical practice. Finally, we discuss how endoscopy and a “treat-to-target” approach may be utilized in clinical practice.
Original languageEnglish
Title of host publicationCrohn's Disease and Ulcerative Colitis
Subtitle of host publicationFrom Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach
EditorsDaniel C Baumgart
Place of PublicationNew York NY USA
PublisherSpringer
Pages267 - 277
Number of pages11
Edition2nd
ISBN (Electronic)978-3-319-33703-6
ISBN (Print)978-3-319-33701-2
DOIs
Publication statusPublished - 2017

Cite this

Christensen, B., & Rubin, D. T. (2017). Objective assessment of endoscopic disease activity and mucosal healing. In D. C. Baumgart (Ed.), Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach (2nd ed., pp. 267 - 277). New York NY USA: Springer. https://doi.org/10.1007/978-3-319-33703-6_24
Christensen, Britt ; Rubin, David T. / Objective assessment of endoscopic disease activity and mucosal healing. Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach. editor / Daniel C Baumgart. 2nd. ed. New York NY USA : Springer, 2017. pp. 267 - 277
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Christensen, B & Rubin, DT 2017, Objective assessment of endoscopic disease activity and mucosal healing. in DC Baumgart (ed.), Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach. 2nd edn, Springer, New York NY USA, pp. 267 - 277. https://doi.org/10.1007/978-3-319-33703-6_24

Objective assessment of endoscopic disease activity and mucosal healing. / Christensen, Britt; Rubin, David T.

Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach. ed. / Daniel C Baumgart. 2nd. ed. New York NY USA : Springer, 2017. p. 267 - 277.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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AB - In patients with inflammatory bowel disease, mucosal healing is associated with improved clinical outcomes including prolonged remission, decreased hospitalizations and surgery, and decreased colorectal cancer risk. Objective assessment of endoscopic disease activity and treating to achieve mucosal healing is increasingly being incorporated as an endpoint in clinical trials and as part of standard clinical care. However currently there is no consensus on the definition of mucosal improvement and healing and there are limited validated endoscopic scoring systems available. This chapter discusses the role of endoscopy and mucosal disease activity in prognosticating the disease course and the benefits of achieving mucosal healing in IBD. In addition, we critically analyze the currently available endoscopic scoring systems from the point of view of clinical trials and clinical practice. Finally, we discuss how endoscopy and a “treat-to-target” approach may be utilized in clinical practice.

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Christensen B, Rubin DT. Objective assessment of endoscopic disease activity and mucosal healing. In Baumgart DC, editor, Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach. 2nd ed. New York NY USA: Springer. 2017. p. 267 - 277 https://doi.org/10.1007/978-3-319-33703-6_24