Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation

Hany S Abed, Chrishan Surendran Samuel, Dennis H Lau, Darren James Kelly, Simon Guy Royce, Muayad Alasady, Rajiv Mahajan, Pawel Kuklik, Yuan (Michael) Zhang, Anthony G Brooks, Adam J Nelson, Stephen G Worthley, Walter Abhayaratna, Johnathon Kalman, Gary G Wittert, Prashanthan Sanders

Research output: Contribution to journalArticleResearchpeer-review

158 Citations (Scopus)

Abstract

BACKGROUND: Obesity is associated with atrial fibrillation (AF); however, the mechanisms by which it induces AF are unknown. OBJECTIVE: To examine the effect of progressive weight gain on the substrate for AF. METHODS: Thirty sheep were studied at baseline, 4 months, and 8 months, following a high-calorie diet. Ten sheep were sampled at each time point for cardiac magnetic resonance imaging and hemodynamic studies. High-density multisite biatrial epicardial mapping was used to quantify effective refractory period, conduction velocity, and conduction heterogeneity index at 4 pacing cycle lengths and AF inducibility. Histology was performed for atrial fibrosis, inflammation, and intramyocardial lipidosis, and molecular analysis was performed for endothelin-A and -B receptors, endothelin-1 peptide, platelet-derived growth factor, transforming growth factor beta1, and connective tissue growth factor. RESULTS: Increasing weight was associated with increasing left atrial volume (P = .01), fibrosis (P = .02), inflammatory infiltrates (P = .01), and lipidosis (P = .02). While there was no change in the effective refractory period (P = .2), there was a decrease in conduction velocity (P
Original languageEnglish
Pages (from-to)90 - 100
Number of pages11
JournalHeart Rhythm
Volume10
Issue number1
DOIs
Publication statusPublished - 2013

Cite this

Abed, Hany S ; Samuel, Chrishan Surendran ; Lau, Dennis H ; Kelly, Darren James ; Royce, Simon Guy ; Alasady, Muayad ; Mahajan, Rajiv ; Kuklik, Pawel ; Zhang, Yuan (Michael) ; Brooks, Anthony G ; Nelson, Adam J ; Worthley, Stephen G ; Abhayaratna, Walter ; Kalman, Johnathon ; Wittert, Gary G ; Sanders, Prashanthan. / Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation. In: Heart Rhythm. 2013 ; Vol. 10, No. 1. pp. 90 - 100.
@article{fac28c4a9002493fa1e400ac4dd2287d,
title = "Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation",
abstract = "BACKGROUND: Obesity is associated with atrial fibrillation (AF); however, the mechanisms by which it induces AF are unknown. OBJECTIVE: To examine the effect of progressive weight gain on the substrate for AF. METHODS: Thirty sheep were studied at baseline, 4 months, and 8 months, following a high-calorie diet. Ten sheep were sampled at each time point for cardiac magnetic resonance imaging and hemodynamic studies. High-density multisite biatrial epicardial mapping was used to quantify effective refractory period, conduction velocity, and conduction heterogeneity index at 4 pacing cycle lengths and AF inducibility. Histology was performed for atrial fibrosis, inflammation, and intramyocardial lipidosis, and molecular analysis was performed for endothelin-A and -B receptors, endothelin-1 peptide, platelet-derived growth factor, transforming growth factor beta1, and connective tissue growth factor. RESULTS: Increasing weight was associated with increasing left atrial volume (P = .01), fibrosis (P = .02), inflammatory infiltrates (P = .01), and lipidosis (P = .02). While there was no change in the effective refractory period (P = .2), there was a decrease in conduction velocity (P",
author = "Abed, {Hany S} and Samuel, {Chrishan Surendran} and Lau, {Dennis H} and Kelly, {Darren James} and Royce, {Simon Guy} and Muayad Alasady and Rajiv Mahajan and Pawel Kuklik and Zhang, {Yuan (Michael)} and Brooks, {Anthony G} and Nelson, {Adam J} and Worthley, {Stephen G} and Walter Abhayaratna and Johnathon Kalman and Wittert, {Gary G} and Prashanthan Sanders",
year = "2013",
doi = "10.1016/j.hrthm.2012.08.043",
language = "English",
volume = "10",
pages = "90 -- 100",
journal = "Heart Rhythm",
issn = "1547-5271",
publisher = "Elsevier",
number = "1",

}

Abed, HS, Samuel, CS, Lau, DH, Kelly, DJ, Royce, SG, Alasady, M, Mahajan, R, Kuklik, P, Zhang, YM, Brooks, AG, Nelson, AJ, Worthley, SG, Abhayaratna, W, Kalman, J, Wittert, GG & Sanders, P 2013, 'Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation', Heart Rhythm, vol. 10, no. 1, pp. 90 - 100. https://doi.org/10.1016/j.hrthm.2012.08.043

Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation. / Abed, Hany S; Samuel, Chrishan Surendran; Lau, Dennis H; Kelly, Darren James; Royce, Simon Guy; Alasady, Muayad; Mahajan, Rajiv; Kuklik, Pawel; Zhang, Yuan (Michael); Brooks, Anthony G; Nelson, Adam J; Worthley, Stephen G; Abhayaratna, Walter; Kalman, Johnathon; Wittert, Gary G; Sanders, Prashanthan.

In: Heart Rhythm, Vol. 10, No. 1, 2013, p. 90 - 100.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation

AU - Abed, Hany S

AU - Samuel, Chrishan Surendran

AU - Lau, Dennis H

AU - Kelly, Darren James

AU - Royce, Simon Guy

AU - Alasady, Muayad

AU - Mahajan, Rajiv

AU - Kuklik, Pawel

AU - Zhang, Yuan (Michael)

AU - Brooks, Anthony G

AU - Nelson, Adam J

AU - Worthley, Stephen G

AU - Abhayaratna, Walter

AU - Kalman, Johnathon

AU - Wittert, Gary G

AU - Sanders, Prashanthan

PY - 2013

Y1 - 2013

N2 - BACKGROUND: Obesity is associated with atrial fibrillation (AF); however, the mechanisms by which it induces AF are unknown. OBJECTIVE: To examine the effect of progressive weight gain on the substrate for AF. METHODS: Thirty sheep were studied at baseline, 4 months, and 8 months, following a high-calorie diet. Ten sheep were sampled at each time point for cardiac magnetic resonance imaging and hemodynamic studies. High-density multisite biatrial epicardial mapping was used to quantify effective refractory period, conduction velocity, and conduction heterogeneity index at 4 pacing cycle lengths and AF inducibility. Histology was performed for atrial fibrosis, inflammation, and intramyocardial lipidosis, and molecular analysis was performed for endothelin-A and -B receptors, endothelin-1 peptide, platelet-derived growth factor, transforming growth factor beta1, and connective tissue growth factor. RESULTS: Increasing weight was associated with increasing left atrial volume (P = .01), fibrosis (P = .02), inflammatory infiltrates (P = .01), and lipidosis (P = .02). While there was no change in the effective refractory period (P = .2), there was a decrease in conduction velocity (P

AB - BACKGROUND: Obesity is associated with atrial fibrillation (AF); however, the mechanisms by which it induces AF are unknown. OBJECTIVE: To examine the effect of progressive weight gain on the substrate for AF. METHODS: Thirty sheep were studied at baseline, 4 months, and 8 months, following a high-calorie diet. Ten sheep were sampled at each time point for cardiac magnetic resonance imaging and hemodynamic studies. High-density multisite biatrial epicardial mapping was used to quantify effective refractory period, conduction velocity, and conduction heterogeneity index at 4 pacing cycle lengths and AF inducibility. Histology was performed for atrial fibrosis, inflammation, and intramyocardial lipidosis, and molecular analysis was performed for endothelin-A and -B receptors, endothelin-1 peptide, platelet-derived growth factor, transforming growth factor beta1, and connective tissue growth factor. RESULTS: Increasing weight was associated with increasing left atrial volume (P = .01), fibrosis (P = .02), inflammatory infiltrates (P = .01), and lipidosis (P = .02). While there was no change in the effective refractory period (P = .2), there was a decrease in conduction velocity (P

UR - http://www.sciencedirect.com/science/article/pii/S1547527112009770

U2 - 10.1016/j.hrthm.2012.08.043

DO - 10.1016/j.hrthm.2012.08.043

M3 - Article

VL - 10

SP - 90

EP - 100

JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

IS - 1

ER -