Obesity during pregnancy in rats adversely influences brain function in the offspring as adults

Helena C. Parkington; Ammar A. Abdulwahid; Farshad A. Mansouri; David Finkelstein; Harold A. Coleman

doi:10.1016/j.orcp.2018.11.158

Obesity during pregnancy in rats adversely influences brain function in the offspring as adults

Helena C. Parkington, Ammar A. Abdulwahid, Farshad A. Mansouri, David Finkelstein, Harold A. Coleman

Research output: Contribution to conference › Abstract › peer-review

Abstract

Obesity is a low-grade inflammatory state and a fetus developing in such an inflammatory milieu is susceptible to developing various disorders. After birth, children of obese mothers are at increased risk of obesity, metabolic syndrome and neurodevelopmental abnormalities, eg reduced cognitive capacity, developmental delay, attention deficit hyperactivity disorder schizophrenia, and autism spectrum disorders. Here we used rats to test the effects of maternal obesity on neuronal networking and to determine if establishing a good diet at weaning could rescue deficits.
Rats gestated and maintained on an obesogenic Western diet (WD) had impaired spatial and working memory compared with rats on control chow (CC) at 10 weeks of age. Switching to CC when 3 weeks old completely rescued working memory but had no effect on spatial memory. Brain slices from 15 week old WD male rats had

Original language	English
Pages	290
Number of pages	1
DOIs	https://doi.org/10.1016/j.orcp.2018.11.158
Publication status	Published - Jun 2019

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10.1016/j.orcp.2018.11.158

Cite this

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title = "Obesity during pregnancy in rats adversely influences brain function in the offspring as adults",

abstract = "Obesity is a low-grade inflammatory state and a fetus developing in such an inflammatory milieu is susceptible to developing various disorders. After birth, children of obese mothers are at increased risk of obesity, metabolic syndrome and neurodevelopmental abnormalities, eg reduced cognitive capacity, developmental delay, attention deficit hyperactivity disorder schizophrenia, and autism spectrum disorders. Here we used rats to test the effects of maternal obesity on neuronal networking and to determine if establishing a good diet at weaning could rescue deficits.Rats gestated and maintained on an obesogenic Western diet (WD) had impaired spatial and working memory compared with rats on control chow (CC) at 10 weeks of age. Switching to CC when 3 weeks old completely rescued working memory but had no effect on spatial memory. Brain slices from 15 week old WD male rats had",

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AU - Parkington, Helena C.

AU - Abdulwahid, Ammar A.

AU - Mansouri, Farshad A.

AU - Finkelstein, David

AU - Coleman, Harold A.

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