Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

Marcus Grohmann, Florian Wiede, Garron T. Dodd, Esteban N. Gurzov, Geraldine J. Ooi, Tariq Butt, Aliki A. Rasmiena, Supreet Kaur, Twishi Gulati, Pei K. Goh, Aislinn E. Treloar, Stuart Archer, Wendy A. Brown, Mathias Muller, Matthew J. Watt, Osamu Ohara, Catriona A. McLean, Tony Tiganis

Research output: Contribution to journalArticleResearchpeer-review

208 Citations (Scopus)


Obesity is a major driver of cancer, especially hepatocellular carcinoma (HCC). The prevailing view is that non-alcoholic steatohepatitis (NASH) and fibrosis or cirrhosis are required for HCC in obesity. Here, we report that NASH and fibrosis and HCC in obesity can be dissociated. We show that the oxidative hepatic environment in obesity inactivates the STAT-1 and STAT-3 phosphatase T cell protein tyrosine phosphatase (TCPTP) and increases STAT-1 and STAT-3 signaling. TCPTP deletion in hepatocytes promoted T cell recruitment and ensuing NASH and fibrosis as well as HCC in obese C57BL/6 mice that normally do not develop NASH and fibrosis or HCC. Attenuating the enhanced STAT-1 signaling prevented T cell recruitment and NASH and fibrosis but did not prevent HCC. By contrast, correcting STAT-3 signaling prevented HCC without affecting NASH and fibrosis. TCPTP-deletion in hepatocytes also markedly accelerated HCC in mice treated with a chemical carcinogen that promotes HCC without NASH and fibrosis. Our studies reveal how obesity-associated hepatic oxidative stress can independently contribute to the pathogenesis of NASH, fibrosis, and HCC.

Original languageEnglish
Pages (from-to)1289-1306
Number of pages18
Issue number5
Publication statusPublished - 15 Nov 2018


  • fibrosis
  • hepatocellular carcinoma
  • non-alcoholic steatohepatitis
  • nonalcoholic fatty liver disease
  • obesity
  • oxidative stress
  • protein tyrosine phosphatase
  • PTPN2
  • STAT-1
  • STAT-3
  • T cells

Cite this