Obesity, arthritis, and gout

Osteoarthritis (OA) is the most prevalent chronic joint disease, characterized by pain and loss of function attributable to changes affecting the whole joint, including articular cartilage and subchondral bone, which result in radiological changes. The knee, hip, and hand joints are most commonly affected. Treatments for OA are largely symptomatic, including paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) for pain relief and total joint replacement for the treatment of end-stage symptomatic OA. Therapy aimed at reducing disease progression is limited.