TY - JOUR
T1 - Obesity and the Risk of Infertility, Gestational Diabetes, and Type 2 Diabetes in Polycystic Ovary Syndrome
AU - Pirotta, Stephanie
AU - Joham, Anju
AU - Grieger, Jessica A.
AU - Tay, Chau Tien
AU - Bahri-Khomami, Mahnaz
AU - Lujan, Marla
AU - Lim, Siew S.
AU - Moran, Lisa J.
N1 - Funding Information:
S.P. received the Post Publication Award from Monash University. L.J.M. received the National Heart Foundation of Australia Future Leader Fellowship from the National Heart Foundation of Australia. S.L. received the Early Career Fellowship from the National Health and Medical Research Council.
Funding Information:
The authors would like to thank and acknowledge the following funding sources: Monash University Post Publication Award, the Collier Charitable Fund, the National Heart Foundation of Australia Future Leader Fellowship, and the National Health and Medical Research Council Early Career Fellowship.
Publisher Copyright:
© 2021. Thieme. All rights reserved.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020/11
Y1 - 2020/11
N2 - This review describes the relationship between obesity and the most common reproductive (infertility) and metabolic (gestational diabetes mellitus [GDM] and type 2 diabetes mellitus [T2DM]) consequences in polycystic ovary syndrome (PCOS). It also describes the vital role of lifestyle management for PCOS. PCOS is a heterogeneous endocrine disorder common in reproductive-age women. Consensus on the exact etiological mechanisms of PCOS is unreached. Overweight or obesity is present in at least 60% of the PCOS population, but the condition occurs irrespective of BMI, with excess BMI increasing both the prevalence and severity of clinical features. Use of lifestyle therapies (nutrition, physical activity, and/or behavioral) for the prevention and management of excess weight gain, infertility, GDM, and T2DM is a vital component of best-practice PCOS care. Lifestyle management is recommended for all women with PCOS as the first-line treatment with or without medications. Due to a lack of high-quality trials demonstrating the efficacy of specific lifestyle approaches, PCOS lifestyle recommendations are as those for the general population. This review summarizes current knowledge relating to obesity and its impact on fertility, GDM, and T2DM. It also summarizes the lifestyle recommendations to best manage these conditions in women with PCOS and obesity.
AB - This review describes the relationship between obesity and the most common reproductive (infertility) and metabolic (gestational diabetes mellitus [GDM] and type 2 diabetes mellitus [T2DM]) consequences in polycystic ovary syndrome (PCOS). It also describes the vital role of lifestyle management for PCOS. PCOS is a heterogeneous endocrine disorder common in reproductive-age women. Consensus on the exact etiological mechanisms of PCOS is unreached. Overweight or obesity is present in at least 60% of the PCOS population, but the condition occurs irrespective of BMI, with excess BMI increasing both the prevalence and severity of clinical features. Use of lifestyle therapies (nutrition, physical activity, and/or behavioral) for the prevention and management of excess weight gain, infertility, GDM, and T2DM is a vital component of best-practice PCOS care. Lifestyle management is recommended for all women with PCOS as the first-line treatment with or without medications. Due to a lack of high-quality trials demonstrating the efficacy of specific lifestyle approaches, PCOS lifestyle recommendations are as those for the general population. This review summarizes current knowledge relating to obesity and its impact on fertility, GDM, and T2DM. It also summarizes the lifestyle recommendations to best manage these conditions in women with PCOS and obesity.
KW - fertility
KW - lifestyle management
KW - polycystic ovary syndrome
UR - http://www.scopus.com/inward/record.url?scp=85104714400&partnerID=8YFLogxK
U2 - 10.1055/s-0041-1726866
DO - 10.1055/s-0041-1726866
M3 - Article
C2 - 33873233
AN - SCOPUS:85104714400
SN - 1526-8004
VL - 38
SP - 342
EP - 351
JO - Seminars in Reproductive Medicine
JF - Seminars in Reproductive Medicine
IS - 6
ER -
