A major challenge in the era of the obesity epidemic is the understanding of mechanisms that mediate obesity-associated diseases. The profound changes seen in obese individuals, such as increased adiposity and metabolic diseases, may be mediated by alterations in microbial composition. Intestinal dysbiosis is not only a consequence of obesity but may promote it. Obesity and a more common consumption of a "Western diet" coincided with an increase in noncommunicable diseases, including most chronic lung diseases. However, experimental evidence that provides a link between obesity-associated microbial alteration and the initiation and progression of respiratory diseases in obesity is limited. In this chapter, we will review the current understanding of obesity-associated alterations on gut microbiota composition, its consequent immunomodulatory properties, and the effects on initiation and progression of respiratory diseases.
|Title of host publication||Mechanisms and Manifestations of Obesity in Lung Disease|
|Editors||Richard A. Johnston, Benjamin T. Suratt|
|Number of pages||20|
|Publication status||Published - 29 Sep 2018|
- Breast milk
- Gut microbiome
- Maternal obesity