Obesity and the microbiome: Big changes on a small scale?

Niki D.J. Ubags, Benjamin J. Marsland

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review


A major challenge in the era of the obesity epidemic is the understanding of mechanisms that mediate obesity-associated diseases. The profound changes seen in obese individuals, such as increased adiposity and metabolic diseases, may be mediated by alterations in microbial composition. Intestinal dysbiosis is not only a consequence of obesity but may promote it. Obesity and a more common consumption of a "Western diet" coincided with an increase in noncommunicable diseases, including most chronic lung diseases. However, experimental evidence that provides a link between obesity-associated microbial alteration and the initiation and progression of respiratory diseases in obesity is limited. In this chapter, we will review the current understanding of obesity-associated alterations on gut microbiota composition, its consequent immunomodulatory properties, and the effects on initiation and progression of respiratory diseases.

Original languageEnglish
Title of host publicationMechanisms and Manifestations of Obesity in Lung Disease
EditorsRichard A. Johnston, Benjamin T. Suratt
Number of pages20
ISBN (Electronic)9780128135549
ISBN (Print)9780128135532
Publication statusPublished - 29 Sep 2018


  • Asthma
  • Breast milk
  • Diet
  • Gut microbiome
  • Maternal obesity
  • Neonatal

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