Obesity and breast cancer: Progress to understanding the relationship

Kristy Brown; Evan R Simpson

doi:10.1158/0008-5472.CAN-09-2257

Obesity and breast cancer: Progress to understanding the relationship

Kristy Brown, Evan R Simpson

Research output: Contribution to journal › Article › Research › peer-review

105 Citations (Scopus)

Abstract

Epidemiological evidence supports a correlation between obesity and breast cancer in women. AMP-activated protein kinase (AMPK) is recognized to be a master regulator of energy homeostasis. One of its actions is to phosphorylate and inhibit the actions of cAMP-responsive element binding protein (CREB)-regulated transcription coactivator 2 (CRTC2). In postmenopausal women, the CREB-dependent regulation of aromatase is a crucial determinant of breast tumor formation through local production of estrogens. We report here that the regulation of aromatase expression in the breast by AMPK and CRTC2, in response to the altered adipokine milieu associated with obesity, provides an important link between obesity and breast cancer risk.

Original language	English
Pages (from-to)	4 - 7
Number of pages	4
Journal	Cancer Research
Volume	70
Issue number	1
DOIs	https://doi.org/10.1158/0008-5472.CAN-09-2257
Publication status	Published - 2010

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10.1158/0008-5472.CAN-09-2257

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AB - Epidemiological evidence supports a correlation between obesity and breast cancer in women. AMP-activated protein kinase (AMPK) is recognized to be a master regulator of energy homeostasis. One of its actions is to phosphorylate and inhibit the actions of cAMP-responsive element binding protein (CREB)-regulated transcription coactivator 2 (CRTC2). In postmenopausal women, the CREB-dependent regulation of aromatase is a crucial determinant of breast tumor formation through local production of estrogens. We report here that the regulation of aromatase expression in the breast by AMPK and CRTC2, in response to the altered adipokine milieu associated with obesity, provides an important link between obesity and breast cancer risk.

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Obesity and breast cancer: Progress to understanding the relationship

Abstract

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