TY - JOUR
T1 - OARSI Clinical Trials Recommendations
T2 - Hand imaging in clinical trials in osteoarthritis
AU - Hunter, D.J.
AU - Arden, N.
AU - Cicuttini, F.
AU - Crema, M. D.
AU - Dardzinski, B.
AU - Duryea, J.
AU - Guermazi, A.
AU - Haugen, I. K.
AU - Kloppenburg, M.
AU - Maheu, E.
AU - Miller, C. G.
AU - Martel-Pelletier, J.
AU - Ochoa-Albíztegui, R. E.
AU - Pelletier, J. P.
AU - Peterfy, C.
AU - Roemer, F.
AU - Gold, G. E.
PY - 2015/5
Y1 - 2015/5
N2 - Tremendous advances have occurred in our understanding of the pathogenesis of hand osteoarthritis (OA) and these are beginning to be applied to trials targeted at modification of the disease course. The purpose of this expert opinion, consensus driven exercise is to provide detail on how one might use and apply hand imaging assessments in disease modifying clinical trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendations/hardware for MRI); commonly encountered problems (including positioning, hardware and coil failures, sequences artifacts); quality assurance/control procedures; measurement methods; measurement performance (reliability, responsiveness, validity); recommendations for trials; and research recommendations.
AB - Tremendous advances have occurred in our understanding of the pathogenesis of hand osteoarthritis (OA) and these are beginning to be applied to trials targeted at modification of the disease course. The purpose of this expert opinion, consensus driven exercise is to provide detail on how one might use and apply hand imaging assessments in disease modifying clinical trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendations/hardware for MRI); commonly encountered problems (including positioning, hardware and coil failures, sequences artifacts); quality assurance/control procedures; measurement methods; measurement performance (reliability, responsiveness, validity); recommendations for trials; and research recommendations.
KW - Guidelines
KW - Hand osteoarthritis
KW - Imaging
UR - http://www.scopus.com/inward/record.url?scp=84933499521&partnerID=8YFLogxK
U2 - 10.1016/j.joca.2015.03.003
DO - 10.1016/j.joca.2015.03.003
M3 - Review Article
C2 - 25952345
AN - SCOPUS:84933499521
SN - 1063-4584
VL - 23
SP - 732
EP - 746
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
IS - 5
ER -